Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers
This book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug–protein in...
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| Year of Publication: | 2022 |
| Language: | English |
| Physical Description: | 1 electronic resource (450 p.) |
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Kutner, Andrzej edt Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (450 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier This book is conceived to promote synergy between research and industrial activities in the design and development of new drugs and, therefore, is not limited to any specific aspect of development. It covers the entire process from the identification of a molecular target, studies of drug–protein interactions, the modeling and optimization of the functional activity, design and chemical synthesis, biological evaluation, and the development of new pharmaceutical carriers.The original articles and reviews are focused on the design and development of new anticancer treatments, new anticancer low-molecular-weight agents as potential drug substances, and the elucidation of their mechanisms of action. The book also includes studies on novel modulators of the serotonergic system used to treat central nervous system disorders, novel agents against infectious diseases, and the development of anti-plasmodial and anti-inflammatory agents. The successful identification of new compounds for development as drug substances comes from rich sources of medicinal plants and medicinal chemistry approaches. English Research & information: general bicssc Chemistry bicssc alpha-ketoglutarate cell cycle apoptosis JNK cell migration cell invasion TGF-β VEGF glycoconjugates methotrexate cancer treatment glucose metabolism drug design and discovery anticancer drugs targeted therapy Warburg effect antidepressants pyrido[1,2-c]pyrimidines dual 5-HT1A/SERT activity drug design anticancer activity lung cancer resveratrol PRI-2191 vitamin D active substance delivery systems biomedical hydrogels active substance-controlled release genistein hydrogels for cosmetology hydrogels for dermatology transdermal active substance delivery systems histone deacetylase (HDAC) depression biomarker anti-depressant therapy human DNA topoisomerase cancer drug molecular docking synthesis fluorine vitamin D3 metabolite A-ring CD-ring side-chain nanoparticles molecular modeling oxidation mechanisms electrochemistry MALDI spectroscopic data cytotoxic study self-assembled monolayer gold electrode multimodal activity calcium-sensing receptor enantiomer calcimimetic calcilytic colon cancer stereospecificity HT-29 IL-8 inflammation cyclooxygenase 1,2,4-triazole pyridazinone SAR anti-inflammatory activity antioxidant activity ADME anticancer drug antimicrobial peptide (AMP) dermaseptin frog skin peptides LHRH prostate cancer Phyllomedusa bicolor therapeutic peptides copper (II) complexes thiourea cytotoxic activity proteome analysis antimicrobial activity major latex protein Chelidonium majus greater celandine defense-related proteins alkaloids cancer cells vitamin D receptor split luciferase-based biosensor CYP24A1-dependent metabolism CYP27B1 rickets genome editing vitamin D biology and action transcription ChIP-chip analysis distal enhancers histone H3 acetylation RNA polymerase II analogue actions at genes vitamin D hormone (1,25(OH)2D3) latex antiviral proteins antimicrobial compounds cytotoxicity drug discovery CRISPR/Cas9 tetrahydro-β-carbolines Plasmodium falciparum (P. falciparum) antimalarial antiparasitic agents hemolysis vitamin D analogs 25 vitamin D 24-hydroxylase CYP24A1 proliferation high-grade serous ovarian cancer cells gold Au(III) complex colorectal cancer organometallic cancer therapy metallodrugs 3-0365-4646-4 3-0365-4645-6 Brown, Geoffrey edt Kallay, Enikö edt Kutner, Andrzej oth Brown, Geoffrey oth Kallay, Enikö oth |
| language |
English |
| format |
eBook |
| author2 |
Brown, Geoffrey Kallay, Enikö Kutner, Andrzej Brown, Geoffrey Kallay, Enikö |
| author_facet |
Brown, Geoffrey Kallay, Enikö Kutner, Andrzej Brown, Geoffrey Kallay, Enikö |
| author2_variant |
a k ak g b gb e k ek |
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HerausgeberIn HerausgeberIn Sonstige Sonstige Sonstige |
| title |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| spellingShingle |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| title_full |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| title_fullStr |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| title_full_unstemmed |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| title_auth |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| title_new |
Novel Strategies in the Development of New Therapies, Drug Substances and Drug Carriers |
| title_sort |
novel strategies in the development of new therapies, drug substances and drug carriers |
| publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
| publishDate |
2022 |
| physical |
1 electronic resource (450 p.) |
| isbn |
3-0365-4646-4 3-0365-4645-6 |
| illustrated |
Not Illustrated |
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