Impaired Mitochondrial Bioenergetics under Pathological Conditions
Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the...
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Lenaz, Giorgio edt Impaired Mitochondrial Bioenergetics under Pathological Conditions Basel MDPI - Multidisciplinary Digital Publishing Institute 2022 1 electronic resource (460 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction. English Research & information: general bicssc Biology, life sciences bicssc Biochemistry bicssc aging heart Bcl-2 family mitochondria programmed cell death fatty acid oxidation palmitate oleate m.3243A> G mutation MT-ATP6 m.8909T> C ATP synthase nephropathy oxidative phosphorylation mitochondrial disease cardiolipin Barth syndrome Sengers syndrome respiratory chain Dilated Cardiomyopathy with Ataxia cardiomyopathy mammalian complex I NADH dehydrogenase complex I assembly complex I structure complex I deficiency supernumerary subunits electron transport chain mitochondrial dysfunction Leigh syndrome mitochondrial diseases yeast Saccharomyces cerevisiae pet mutants pancreatic endocrine cells mathematical model cellular bioenergetics diabetes glucagon insulin exercise immune system metabolic disease COVID-19 mitochondrial dynamics viral infections MAVS RIG-I MDA5 innate immune response SARS CoV-2 RSV influenza respiratory supercomplexes ROS ATP synthase/hydrolase mitochondrial permeability transition pore cristae cellular signaling human disease mitochondrial dynamic cell signaling cancer respiratory complexes oxidative stress mitochondrial DNA MTCYB mutations cytochrome b complex III aging energy metabolism entorhinal cortex lipoxidation-derived damage neurodegeneration oxidative damage protein import respiratory complex assembly supercomplexes mitochondrial proteostasis heart failure bioenergetics assembly factor atypical myopathy high-resolution respirometry toxicity assays cell culture equine primary myoblasts fibroblasts frozen tissue leukocytes oxygen consumption platelets respirometry skeletal muscle 3-0365-4648-0 3-0365-4647-2 Nesci, Salvatore edt Lenaz, Giorgio oth Nesci, Salvatore oth |
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English |
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Nesci, Salvatore Lenaz, Giorgio Nesci, Salvatore |
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Nesci, Salvatore Lenaz, Giorgio Nesci, Salvatore |
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g l gl s n sn |
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HerausgeberIn Sonstige Sonstige |
title |
Impaired Mitochondrial Bioenergetics under Pathological Conditions |
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Impaired Mitochondrial Bioenergetics under Pathological Conditions |
title_full |
Impaired Mitochondrial Bioenergetics under Pathological Conditions |
title_fullStr |
Impaired Mitochondrial Bioenergetics under Pathological Conditions |
title_full_unstemmed |
Impaired Mitochondrial Bioenergetics under Pathological Conditions |
title_auth |
Impaired Mitochondrial Bioenergetics under Pathological Conditions |
title_new |
Impaired Mitochondrial Bioenergetics under Pathological Conditions |
title_sort |
impaired mitochondrial bioenergetics under pathological conditions |
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MDPI - Multidisciplinary Digital Publishing Institute |
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2022 |
physical |
1 electronic resource (460 p.) |
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3-0365-4648-0 3-0365-4647-2 |
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Not Illustrated |
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AT lenazgiorgio impairedmitochondrialbioenergeticsunderpathologicalconditions AT nescisalvatore impairedmitochondrialbioenergeticsunderpathologicalconditions |
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Impaired Mitochondrial Bioenergetics under Pathological Conditions |
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