Impaired Mitochondrial Bioenergetics under Pathological Conditions

Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the...

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Year of Publication:2022
Language:English
Physical Description:1 electronic resource (460 p.)
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(oapen)https://directory.doabooks.org/handle/20.500.12854/91183
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spelling Lenaz, Giorgio edt
Impaired Mitochondrial Bioenergetics under Pathological Conditions
Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
1 electronic resource (460 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction.
English
Research & information: general bicssc
Biology, life sciences bicssc
Biochemistry bicssc
aging heart
Bcl-2 family
mitochondria
programmed cell death
fatty acid oxidation
palmitate
oleate
m.3243A&gt
G mutation
MT-ATP6
m.8909T&gt
C
ATP synthase
nephropathy
oxidative phosphorylation
mitochondrial disease
cardiolipin
Barth syndrome
Sengers syndrome
respiratory chain
Dilated Cardiomyopathy with Ataxia
cardiomyopathy
mammalian complex I
NADH dehydrogenase
complex I assembly
complex I structure
complex I deficiency
supernumerary subunits
electron transport chain
mitochondrial dysfunction
Leigh syndrome
mitochondrial diseases
yeast
Saccharomyces cerevisiae
pet mutants
pancreatic endocrine cells
mathematical model
cellular bioenergetics
diabetes
glucagon
insulin
exercise
immune system
metabolic disease
COVID-19
mitochondrial dynamics
viral infections
MAVS
RIG-I
MDA5
innate immune response
SARS CoV-2
RSV
influenza
respiratory supercomplexes
ROS
ATP synthase/hydrolase
mitochondrial permeability transition pore
cristae
cellular signaling
human disease
mitochondrial dynamic
cell signaling
cancer
respiratory complexes
oxidative stress
mitochondrial DNA
MTCYB mutations
cytochrome b
complex III
aging
energy metabolism
entorhinal cortex
lipoxidation-derived damage
neurodegeneration
oxidative damage
protein import
respiratory complex assembly
supercomplexes
mitochondrial proteostasis
heart failure
bioenergetics
assembly factor
atypical myopathy
high-resolution respirometry
toxicity assays
cell culture
equine primary myoblasts
fibroblasts
frozen tissue
leukocytes
oxygen consumption
platelets
respirometry
skeletal muscle
3-0365-4648-0
3-0365-4647-2
Nesci, Salvatore edt
Lenaz, Giorgio oth
Nesci, Salvatore oth
language English
format eBook
author2 Nesci, Salvatore
Lenaz, Giorgio
Nesci, Salvatore
author_facet Nesci, Salvatore
Lenaz, Giorgio
Nesci, Salvatore
author2_variant g l gl
s n sn
author2_role HerausgeberIn
Sonstige
Sonstige
title Impaired Mitochondrial Bioenergetics under Pathological Conditions
spellingShingle Impaired Mitochondrial Bioenergetics under Pathological Conditions
title_full Impaired Mitochondrial Bioenergetics under Pathological Conditions
title_fullStr Impaired Mitochondrial Bioenergetics under Pathological Conditions
title_full_unstemmed Impaired Mitochondrial Bioenergetics under Pathological Conditions
title_auth Impaired Mitochondrial Bioenergetics under Pathological Conditions
title_new Impaired Mitochondrial Bioenergetics under Pathological Conditions
title_sort impaired mitochondrial bioenergetics under pathological conditions
publisher MDPI - Multidisciplinary Digital Publishing Institute
publishDate 2022
physical 1 electronic resource (460 p.)
isbn 3-0365-4648-0
3-0365-4647-2
illustrated Not Illustrated
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is_hierarchy_title Impaired Mitochondrial Bioenergetics under Pathological Conditions
author2_original_writing_str_mv noLinkedField
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