Natural Antibodies in Health and Disease
Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2018 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (180 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993548690904498 |
---|---|
ctrlnum |
(CKB)4920000000094076 (oapen)https://directory.doabooks.org/handle/20.500.12854/54349 (EXLCZ)994920000000094076 |
collection |
bib_alma |
record_format |
marc |
spelling |
Ana Maria Hernandez auth Natural Antibodies in Health and Disease Frontiers Media SA 2018 1 electronic resource (180 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease. English innate immunity immunoglobulin Antibodies B cells IgM natural antibodies B-1 cells 2-88945-405-3 Nichol E. Holodick auth |
language |
English |
format |
eBook |
author |
Ana Maria Hernandez |
spellingShingle |
Ana Maria Hernandez Natural Antibodies in Health and Disease Frontiers Research Topics |
author_facet |
Ana Maria Hernandez Nichol E. Holodick |
author_variant |
a m h amh |
author2 |
Nichol E. Holodick |
author2_variant |
n e h neh |
author_sort |
Ana Maria Hernandez |
title |
Natural Antibodies in Health and Disease |
title_full |
Natural Antibodies in Health and Disease |
title_fullStr |
Natural Antibodies in Health and Disease |
title_full_unstemmed |
Natural Antibodies in Health and Disease |
title_auth |
Natural Antibodies in Health and Disease |
title_new |
Natural Antibodies in Health and Disease |
title_sort |
natural antibodies in health and disease |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2018 |
physical |
1 electronic resource (180 p.) |
isbn |
2-88945-405-3 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT anamariahernandez naturalantibodiesinhealthanddisease AT nicholeholodick naturalantibodiesinhealthanddisease |
status_str |
n |
ids_txt_mv |
(CKB)4920000000094076 (oapen)https://directory.doabooks.org/handle/20.500.12854/54349 (EXLCZ)994920000000094076 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Natural Antibodies in Health and Disease |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField |
_version_ |
1787548684547784705 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02922nam-a2200361z--4500</leader><controlfield tag="001">993548690904498</controlfield><controlfield tag="005">20231214133256.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2018 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)4920000000094076</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/54349</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)994920000000094076</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ana Maria Hernandez</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Natural Antibodies in Health and Disease</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (180 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">innate immunity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">immunoglobulin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Antibodies</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">B cells</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">IgM</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">natural antibodies</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">B-1 cells</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88945-405-3</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nichol E. Holodick</subfield><subfield code="4">auth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:48:57 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2019-11-10 04:18:40 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338849790004498&Force_direct=true</subfield><subfield code="Z">5338849790004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338849790004498</subfield></datafield></record></collection> |