DNA Replication Stress

DNA Replication Stress

This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid tran...

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Brosh Jr, Robert M.
Year of Publication:2019
Language:English
Physical Description:1 electronic resource (368 p.)
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record_format marc
spelling Brosh Jr, Robert M. auth
DNA Replication Stress
MDPI - Multidisciplinary Digital Publishing Institute 2019
1 electronic resource (368 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
English
Werner Syndrome
A549 cells
epigenetic
neurodegeneration
Genome integrity
adaptation
cellular senescence
genome instability
Werner Syndrome Protein
lipofuscin
cell cycle checkpoints
exonuclease 1
template-switching
energy metabolism
mutation frequency
DNA replication
fork regression
motor neuron disease
Microsatellites
Alzheimer's disease
chromatin remodeler
repair of DNA damage
AP site analogue
mutagens
replication timing
Thermococcus eurythermalis
nucleolar stress
gene expression
mutations spectra
origin firing
Fanconi Anemia
superfamily 2 ATPase
DNA translocation
DNA repair
SSB signaling
homologous recombination
common fragile sites
8-chloro-adenosine
replication
genome stability
mutagenicity
fork reversal
multiple sclerosis
non-B DNA
protein stability
heterogeneity
ubiquitin
SenTraGorTM (GL13)
replication restart
EdU
?-arrestin
NER
aging
SSB end resection
oxidative stress
ATR
dormant origins
R loops
DNA damage response
Difficult-to-Replicate Sequences
DNA double-strand repair
endonuclease IV
ALS
double strand break repair
premature aging
replication stress
EXO1
POL?
translesion synthesis
strand displacements
G2-arrest
DNA replication pattern
SSB repair
genome integrity
G protein-coupled receptor kinase interacting protein 2 (GIT2)
MMR
replicative stress
senolytics
spacer
interactome
ATR-Chk1 DDR pathway
C9orf72
replication fork restart
translesion DNA synthesis
DNA damage
mismatch repair
DNA replication stress
DNA helicase
Polymerase kappa
DNA fiber assay
H1299 cells
TLS
APE2
ageing
cell death
chromosome
TopBP1
barley
clock proteins
post-translational modification
8-oxoG
S phase
ataxia telangiectasia mutated (ATM)
G protein-coupled receptor (GPCR)
Polymerase eta
cancer
G protein-coupled receptor kinase (GRK)
helicase
genomic instability
Parkinson's disease
nucleotide excision repair
SupF
3-03921-389-X
language English
format eBook
author Brosh Jr, Robert M.
spellingShingle Brosh Jr, Robert M.
DNA Replication Stress
author_facet Brosh Jr, Robert M.
author_variant j r m b jrm jrmb
author_sort Brosh Jr, Robert M.
title DNA Replication Stress
title_full DNA Replication Stress
title_fullStr DNA Replication Stress
title_full_unstemmed DNA Replication Stress
title_auth DNA Replication Stress
title_new DNA Replication Stress
title_sort dna replication stress
publisher MDPI - Multidisciplinary Digital Publishing Institute
publishDate 2019
physical 1 electronic resource (368 p.)
isbn 3-03921-390-3
3-03921-389-X
illustrated Not Illustrated
work_keys_str_mv AT broshjrrobertm dnareplicationstress
status_str n
ids_txt_mv (CKB)4100000010106097
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(EXLCZ)994100000010106097
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is_hierarchy_title DNA Replication Stress
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