Recent Progress in Solid Dispersion Technology
Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recen...
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Year of Publication: | 2019 |
Language: | English |
Physical Description: | 1 electronic resource (204 p.) |
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100 | 1 | |a Kawakami, Kohsaku |4 auth | |
245 | 1 | 0 | |a Recent Progress in Solid Dispersion Technology |
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300 | |a 1 electronic resource (204 p.) | ||
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520 | |a Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics. | ||
546 | |a English | ||
653 | |a thermodynamic modeling | ||
653 | |a molecular dynamics simulation | ||
653 | |a poorly soluble drugs | ||
653 | |a amorphous solid dispersions | ||
653 | |a dissolution enhancement | ||
653 | |a crystallization tendency | ||
653 | |a continuous processing | ||
653 | |a stability | ||
653 | |a milling | ||
653 | |a granulation | ||
653 | |a thermal analysis | ||
653 | |a amorphous | ||
653 | |a ball milling | ||
653 | |a pharmaceutical glass | ||
653 | |a dissolution | ||
653 | |a rebamipide | ||
653 | |a poloxamer | ||
653 | |a classification | ||
653 | |a polyelectrolytes | ||
653 | |a amorphisation | ||
653 | |a self-assembly | ||
653 | |a dissolution rate | ||
653 | |a miscibility | ||
653 | |a bioavailability | ||
653 | |a solubility | ||
653 | |a evaporation | ||
653 | |a mesoporous | ||
653 | |a polyelectrolyte excipient matrix | ||
653 | |a polymer | ||
653 | |a bicaludamide | ||
653 | |a phase diagram | ||
653 | |a Weibull dissolution model | ||
653 | |a spectroscopic techniques | ||
653 | |a anticancer drugs | ||
653 | |a manufacturing methods | ||
653 | |a nucleation | ||
653 | |a molecular complex | ||
653 | |a nanoaggregates | ||
653 | |a enrofloxacin | ||
653 | |a accelerated stability test | ||
653 | |a solubility enhancement | ||
653 | |a amorphous solid dispersion | ||
653 | |a tadalafil | ||
653 | |a process development | ||
653 | |a amorphous polymeric salt | ||
653 | |a Wood’s apparatus | ||
653 | |a hot melt extrusion | ||
653 | |a solid dispersions | ||
653 | |a intrinsic dissolution rate | ||
653 | |a solid dispersion | ||
653 | |a interaction | ||
653 | |a crystallization | ||
653 | |a spray drying | ||
653 | |a characterization | ||
653 | |a ciprofloxacin | ||
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