Tyrosine Kinases as Druggable Targets in Cancer /

Tyrosine Kinases as Druggable Targets in Cancer / / edited by Huan Ren.

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL...

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TeilnehmendeR:
Ren, Huan,
Place / Publishing House:London, United Kingdom : : IntechOpen,, 2019.
Year of Publication:2019
Language:English
Physical Description:1 online resource (134 pages)
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spelling Ren, Huan edt
Tyrosine Kinases as Druggable Targets in Cancer / edited by Huan Ren.
IntechOpen 2019
London, United Kingdom : IntechOpen, 2019.
1 online resource (134 pages)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Description based on publisher supplied metadata and other sources.
Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment.
English
Oncology.
Oncology
1-78984-808-3
Ren, Huan, editor.
language English
format eBook
author2 Ren, Huan,
author_facet Ren, Huan,
author2_variant h r hr
h r hr
author2_role TeilnehmendeR
title Tyrosine Kinases as Druggable Targets in Cancer /
spellingShingle Tyrosine Kinases as Druggable Targets in Cancer /
title_full Tyrosine Kinases as Druggable Targets in Cancer / edited by Huan Ren.
title_fullStr Tyrosine Kinases as Druggable Targets in Cancer / edited by Huan Ren.
title_full_unstemmed Tyrosine Kinases as Druggable Targets in Cancer / edited by Huan Ren.
title_auth Tyrosine Kinases as Druggable Targets in Cancer /
title_new Tyrosine Kinases as Druggable Targets in Cancer /
title_sort tyrosine kinases as druggable targets in cancer /
publisher IntechOpen
IntechOpen,
publishDate 2019
physical 1 online resource (134 pages)
isbn 1-83962-219-9
1-78984-809-1
1-78984-808-3
callnumber-first R - Medicine
callnumber-subject RC - Internal Medicine
callnumber-label RC261
callnumber-sort RC 3261 T976 42019
illustrated Not Illustrated
dewey-hundreds 600 - Technology
dewey-tens 610 - Medicine & health
dewey-ones 616 - Diseases
dewey-full 616.994
dewey-sort 3616.994
dewey-raw 616.994
dewey-search 616.994
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carrierType_str_mv cr
is_hierarchy_title Tyrosine Kinases as Druggable Targets in Cancer /
author2_original_writing_str_mv noLinkedField
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