Origin and spatiotemporal dynamics of the peroxisomal endomembrane system
The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2015 |
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Series: | Frontiers Research Topics
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Richard A. Rachubinski auth Origin and spatiotemporal dynamics of the peroxisomal endomembrane system Frontiers Media SA 2015 1 electronic resource (148 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell. English peroxisomal endomembrane system development Reactive Oxygen Species Aging peroxisome Lipid Metabolism Endoplasmic Reticulum peroxisome biogenesis 2-88919-464-7 Vladimir I. Titorenko auth |
language |
English |
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eBook |
author |
Richard A. Rachubinski |
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Richard A. Rachubinski Origin and spatiotemporal dynamics of the peroxisomal endomembrane system Frontiers Research Topics |
author_facet |
Richard A. Rachubinski Vladimir I. Titorenko |
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r a r rar |
author2 |
Vladimir I. Titorenko |
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Richard A. Rachubinski |
title |
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
title_full |
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
title_fullStr |
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
title_full_unstemmed |
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
title_auth |
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
title_new |
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
title_sort |
origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2015 |
physical |
1 electronic resource (148 p.) |
isbn |
2-88919-464-7 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT richardarachubinski originandspatiotemporaldynamicsoftheperoxisomalendomembranesystem AT vladimirititorenko originandspatiotemporaldynamicsoftheperoxisomalendomembranesystem |
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n |
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(CKB)3710000000612022 (oapen)https://directory.doabooks.org/handle/20.500.12854/55431 (EXLCZ)993710000000612022 |
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Frontiers Research Topics |
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Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
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Frontiers Research Topics |
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