Natural Products and Drug Discovery
Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terr...
Saved in:
: | |
---|---|
Year of Publication: | 2020 |
Language: | English |
Physical Description: | 1 electronic resource (392 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993548170504498 |
---|---|
ctrlnum |
(CKB)4100000011302270 (oapen)https://directory.doabooks.org/handle/20.500.12854/54359 (EXLCZ)994100000011302270 |
collection |
bib_alma |
record_format |
marc |
spelling |
Avato, Pinarosa auth Natural Products and Drug Discovery MDPI - Multidisciplinary Digital Publishing Institute 2020 1 electronic resource (392 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays. English dihydrochalcones cytotoxicity-guided harpagoside biotechnology synergy Imperata cylindrica 5?-dimethylchalcone (DMC) antioxidant activity marine resources phenolic derivatives secondary metabolites antimicrobial agents antimicrobial resistance metabolomics Humulus lupulus chromatography stereochemistry FSE cytokines cytotoxic activity glutamate angiogenesis traditional medicine Ca2+ L6 cell human colon cancer cell lines siphonous green algae anti-inflammatory activity Phyllanthus chamacristoides spectroscopic analysis Physcomitrella patens Leishmania mexicana mexicana dementia prenylated phenolic compounds T2DM HPLC-ESI-microTOF-Q-MS/MS Eruca sativa Dryopteris fragrans chemosystematics 2? cerebellum Cleistocalyx operculatus inflammation multivariate data analysis Phyllanthus orbicularis HPLC cardiovascular disease Kv7 potassium channels marine peptides proliferation sulfated coumarins Orobanche s.l. phenylpropanoid glycosides Harpagophytum procumbens sesquiterpenoids TRPV1 Fideloside phenylethanoid glycosides Cuba molecular network NMR ketamine aging GLUT4 diabetes oxidative stress Lamiales circular dichroism psychosis antinociceptive immuno-regulation activity terpenoids NADPH oxidases diabetic neuropathy spagyric tincture H2S celastrol isolation and quantification 4?-dihydroxy-6?-methoxy-3? Leea indica C-glycoside neuropathic pain PANC-1 glucosinolates flavonoids bioactivities of natural products cardamonin isoflavones terpenes methicillin-resistant Staphylococcus aureus malaria artemisinin natural products devil's claw ACE inhibitory peptide pPancreatic cancer growth inhibitory activity mass spectrometry flavonoid phenolics Astragalus boeticus L. proanthocyanidins opioid Trifolium Trypanosoma brucei brucei acetylated astragalosides Fabaceae bioactive peptides LC-MS Dasycladus vermicularis Orobanchaceae migration glucoerucin ESI-MS/MS cancer zebrafish antihypertensive Bacopa monnieri chemical derivatization hypertension 3-03928-746-X |
language |
English |
format |
eBook |
author |
Avato, Pinarosa |
spellingShingle |
Avato, Pinarosa Natural Products and Drug Discovery |
author_facet |
Avato, Pinarosa |
author_variant |
p a pa |
author_sort |
Avato, Pinarosa |
title |
Natural Products and Drug Discovery |
title_full |
Natural Products and Drug Discovery |
title_fullStr |
Natural Products and Drug Discovery |
title_full_unstemmed |
Natural Products and Drug Discovery |
title_auth |
Natural Products and Drug Discovery |
title_new |
Natural Products and Drug Discovery |
title_sort |
natural products and drug discovery |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
physical |
1 electronic resource (392 p.) |
isbn |
3-03928-747-8 3-03928-746-X |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT avatopinarosa naturalproductsanddrugdiscovery |
status_str |
n |
ids_txt_mv |
(CKB)4100000011302270 (oapen)https://directory.doabooks.org/handle/20.500.12854/54359 (EXLCZ)994100000011302270 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Natural Products and Drug Discovery |
_version_ |
1796652178399559680 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>06269nam-a2201705z--4500</leader><controlfield tag="001">993548170504498</controlfield><controlfield tag="005">20231214133650.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2020 xx |||||o ||| 0|eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3-03928-747-8</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)4100000011302270</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/54359</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)994100000011302270</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Avato, Pinarosa</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Natural Products and Drug Discovery</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">MDPI - Multidisciplinary Digital Publishing Institute</subfield><subfield code="c">2020</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (392 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">dihydrochalcones</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytotoxicity-guided</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">harpagoside</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">biotechnology</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">synergy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Imperata cylindrica</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">5?-dimethylchalcone (DMC)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antioxidant activity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">marine resources</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phenolic derivatives</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">secondary metabolites</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antimicrobial agents</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antimicrobial resistance</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">metabolomics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Humulus lupulus</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">chromatography</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">stereochemistry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">FSE</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytokines</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cytotoxic activity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">glutamate</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">angiogenesis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">traditional medicine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Ca2+</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">L6 cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">human colon cancer cell lines</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">siphonous green algae</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">anti-inflammatory activity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Phyllanthus chamacristoides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">spectroscopic analysis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Physcomitrella patens</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Leishmania mexicana mexicana</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">dementia</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">prenylated phenolic compounds</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">T2DM</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">HPLC-ESI-microTOF-Q-MS/MS</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Eruca sativa</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Dryopteris fragrans</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">chemosystematics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">2?</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cerebellum</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Cleistocalyx operculatus</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">inflammation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">multivariate data analysis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Phyllanthus orbicularis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">HPLC</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cardiovascular disease</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Kv7 potassium channels</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">marine peptides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">proliferation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">sulfated coumarins</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Orobanche s.l.</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phenylpropanoid glycosides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Harpagophytum procumbens</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">sesquiterpenoids</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">TRPV1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Fideloside</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phenylethanoid glycosides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Cuba</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">molecular network</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">NMR</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ketamine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">aging</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">GLUT4</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">diabetes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">oxidative stress</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Lamiales</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">circular dichroism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">psychosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antinociceptive</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">immuno-regulation activity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">terpenoids</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">NADPH oxidases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">diabetic neuropathy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">spagyric tincture</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">H2S</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">celastrol</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">isolation and quantification</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">4?-dihydroxy-6?-methoxy-3?</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Leea indica</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">C-glycoside</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">neuropathic pain</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">PANC-1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">glucosinolates</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">flavonoids</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">bioactivities of natural products</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cardamonin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">isoflavones</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">terpenes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">methicillin-resistant Staphylococcus aureus</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">malaria</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">artemisinin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">natural products</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">devil's claw</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ACE inhibitory peptide</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pPancreatic cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">growth inhibitory activity</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mass spectrometry</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">flavonoid</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phenolics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Astragalus boeticus L.</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">proanthocyanidins</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">opioid</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Trifolium</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Trypanosoma brucei brucei</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">acetylated astragalosides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Fabaceae</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">bioactive peptides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LC-MS</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Dasycladus vermicularis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Orobanchaceae</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">migration</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">glucoerucin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ESI-MS/MS</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">zebrafish</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">antihypertensive</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Bacopa monnieri</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">chemical derivatization</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">hypertension</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-03928-746-X</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 06:01:53 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2020-06-20 22:16:43 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338743740004498&Force_direct=true</subfield><subfield code="Z">5338743740004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338743740004498</subfield></datafield></record></collection> |