Curcumin in Health and Disease
The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecula...
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Year of Publication: | 2019 |
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Physical Description: | 1 electronic resource (274 p.) |
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Bachmeier, Beatrice auth Curcumin in Health and Disease MDPI - Multidisciplinary Digital Publishing Institute 2019 1 electronic resource (274 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases. English minerals cancer treatment chitosan neurodegeneration antioxidant activity senescence tumor proliferation nanoparticles antimicrobial agents oxidative metabolites drug discovery Akt/mTOR signaling micronutrients ulcerative colitis transmission electron microscopy metabolic reprogramming curcumin death receptor chaperone-mediated autophagy wound healing brain ischemia autophagy Alzheimer's disease genes transthyretin inflammatory bowel disease cellular pathway centrifugal partition chromatography nutrition amyloid Curcuma longa protein aggregation supportive care IL-17 senolytics complementary medicine macronutrients structure activity relationship gastroprotection Zingiberaceae anti-inflamation TLC bioautography microbiota glioblastoma multiforme amyloidosis SHMT2 antioxidants silica apoptosis reflux esophagitis gastric ulcer TLC-MS anti-cancer anticancer ImageJ anti-tumor delivery system wound Helicobacter pylori direct protein binding protein misfolding tumor growth diet Crohn's disease hydrostatic counter-current chromatography ageing renal cell cancer gastric cancer amino-acids STAT3 mechanism of action inflamm-aging mitophagy necrotizing enterocolitis cell cycling vitamins turmeric tuber cancer tau protein 3-03921-449-7 |
language |
English |
format |
eBook |
author |
Bachmeier, Beatrice |
spellingShingle |
Bachmeier, Beatrice Curcumin in Health and Disease |
author_facet |
Bachmeier, Beatrice |
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b b bb |
author_sort |
Bachmeier, Beatrice |
title |
Curcumin in Health and Disease |
title_full |
Curcumin in Health and Disease |
title_fullStr |
Curcumin in Health and Disease |
title_full_unstemmed |
Curcumin in Health and Disease |
title_auth |
Curcumin in Health and Disease |
title_new |
Curcumin in Health and Disease |
title_sort |
curcumin in health and disease |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2019 |
physical |
1 electronic resource (274 p.) |
isbn |
3-03921-450-0 3-03921-449-7 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT bachmeierbeatrice curcumininhealthanddisease |
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n |
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(CKB)4100000010106180 (oapen)https://directory.doabooks.org/handle/20.500.12854/44401 (EXLCZ)994100000010106180 |
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Curcumin in Health and Disease |
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1787548669059268608 |
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