Morphogens in the wiring of the nervous system
Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and t...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (238 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993548114704498 |
---|---|
ctrlnum |
(CKB)3710000000631044 (oapen)https://directory.doabooks.org/handle/20.500.12854/53954 (EXLCZ)993710000000631044 |
collection |
bib_alma |
record_format |
marc |
spelling |
Nelson Osses auth Morphogens in the wiring of the nervous system Frontiers Media SA 2016 1 electronic resource (238 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules commanding tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring and function in the developing and mature nervous system. Accordingly, dysfunctions of the signaling pathways activated by these molecules contribute to synaptic disassembly and altered function in diseases affecting the nervous system. We consider it timely to bring together cumulative evidence pointing to crucial roles for signaling activated by different morphogens in the establishment of precise contacts between neurons and their synaptic partners. Therefore, this research topic issue combines review and research articles aimed to cover the functional relevance of such morphogens on the different steps involved in synaptic assembly and function. Diverse model systems of physiological or pathological conditions have been included, as well as different cellular, biochemical and molecular approaches. Altogether, they contribute in different and complementary ways to build a holistic view of the roles that early development morphogens play during the assembly, maintenance and/or regeneration of functional synapses. English Shh Nervous System BMP neurodegeneration synapse Wnt Morphogens Neurogenesis 2-88919-781-6 Juan Pablo Henriquez auth |
language |
English |
format |
eBook |
author |
Nelson Osses |
spellingShingle |
Nelson Osses Morphogens in the wiring of the nervous system Frontiers Research Topics |
author_facet |
Nelson Osses Juan Pablo Henriquez |
author_variant |
n o no |
author2 |
Juan Pablo Henriquez |
author2_variant |
j p h jph |
author_sort |
Nelson Osses |
title |
Morphogens in the wiring of the nervous system |
title_full |
Morphogens in the wiring of the nervous system |
title_fullStr |
Morphogens in the wiring of the nervous system |
title_full_unstemmed |
Morphogens in the wiring of the nervous system |
title_auth |
Morphogens in the wiring of the nervous system |
title_new |
Morphogens in the wiring of the nervous system |
title_sort |
morphogens in the wiring of the nervous system |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (238 p.) |
isbn |
2-88919-781-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT nelsonosses morphogensinthewiringofthenervoussystem AT juanpablohenriquez morphogensinthewiringofthenervoussystem |
status_str |
n |
ids_txt_mv |
(CKB)3710000000631044 (oapen)https://directory.doabooks.org/handle/20.500.12854/53954 (EXLCZ)993710000000631044 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Morphogens in the wiring of the nervous system |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField |
_version_ |
1796651924644167680 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02889nam-a2200373z--4500</leader><controlfield tag="001">993548114704498</controlfield><controlfield tag="005">20231214133620.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2016 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000631044</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/53954</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000631044</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Nelson Osses</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Morphogens in the wiring of the nervous system</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (238 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Neuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules commanding tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring and function in the developing and mature nervous system. Accordingly, dysfunctions of the signaling pathways activated by these molecules contribute to synaptic disassembly and altered function in diseases affecting the nervous system. We consider it timely to bring together cumulative evidence pointing to crucial roles for signaling activated by different morphogens in the establishment of precise contacts between neurons and their synaptic partners. Therefore, this research topic issue combines review and research articles aimed to cover the functional relevance of such morphogens on the different steps involved in synaptic assembly and function. Diverse model systems of physiological or pathological conditions have been included, as well as different cellular, biochemical and molecular approaches. Altogether, they contribute in different and complementary ways to build a holistic view of the roles that early development morphogens play during the assembly, maintenance and/or regeneration of functional synapses.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Shh</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Nervous System</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">BMP</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">neurodegeneration</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">synapse</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Wnt</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Morphogens</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Neurogenesis</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-781-6</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Juan Pablo Henriquez</subfield><subfield code="4">auth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:59:20 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2016-04-12 04:07:06 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338706890004498&Force_direct=true</subfield><subfield code="Z">5338706890004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338706890004498</subfield></datafield></record></collection> |