Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases /
Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and che...
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Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (163 pages) :; illustrations; digital, PDF file(s). |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
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Konrad Krzewski auth Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / Frontiers Media SA 2015 France : Frontiers Media SA, 2015 1 online resource (163 pages) : illustrations; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity. English Includes bibliographical references. Microbiology & Immunology HILCC Biology HILCC Health & Biological Sciences HILCC secretory lysosomes NK cells hemophagocytic histiocytosis immune therapy granzyme lytic granules Cytotoxicity anti-tumor response Immunological Synapse Perforin Krzewski, Konrad editor. Bryceson, Yenan editor. |
language |
English |
format |
eBook |
author |
Konrad Krzewski |
spellingShingle |
Konrad Krzewski Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / Frontiers Research Topics |
author_facet |
Konrad Krzewski Krzewski, Konrad Bryceson, Yenan |
author_variant |
k k kk |
author2 |
Krzewski, Konrad Bryceson, Yenan |
author2_variant |
k k kk y b yb |
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TeilnehmendeR TeilnehmendeR |
author_sort |
Konrad Krzewski |
title |
Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
title_full |
Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
title_fullStr |
Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
title_full_unstemmed |
Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
title_auth |
Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
title_new |
Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
title_sort |
molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (163 pages) : illustrations; digital, PDF file(s). |
isbn |
9782889192793 |
callnumber-first |
Q - Science |
callnumber-subject |
QR - Microbiology |
callnumber-label |
QR185 |
callnumber-sort |
QR 3185.8 L9 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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status_str |
n |
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Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / |
author2_original_writing_str_mv |
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