Advances in epithelial ovarian cancer : model systems, microenvironmental influences, therapy, and origins / / edited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata.
This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influen...
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Superior document: | Frontiers Research Topics |
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Place / Publishing House: | [Lausanne, Switzerland] : : Frontiers Media SA,, 2016. ©2016 |
Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers in oncology.
Frontiers research topics. |
Physical Description: | 1 online resource (176 pages) :; illustrations; digital, PDF file(s). |
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Ben Davidson auth Advances in epithelial ovarian cancer [electronic resource] : model systems, microenvironmental influences, therapy, and origins / edited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata. Frontiers Media SA 2016 [Lausanne, Switzerland] : Frontiers Media SA, 2016. ©2016 1 online resource (176 pages) : illustrations; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier. online resource cr rdacarrier text file rda Frontiers Research Topics Frontiers in oncology a Includes bibliographical references. Open access Unrestricted online access star This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a major dilemma as models with the oncogenic aberrations common in the human malignancy do not accurately recapitulate HG-SOC. Conversely, commonly used HG-SOC cell lines have been found to not harbor the expected genetic changes. These issues as well as the rapid acceptance of patient derived xenograft models are reviewed. Five articles discuss different aspects of the tumor microenvironment including its role in therapy resistance, disease progression and metastasis. Mutation of BRCA1/2 continues to be the best defined risk factor for HG-SOC. Three articles discuss BRCA-loss in the context of disease development, targeted therapies and changes in preventative measures proposed for mutation carriers in light of the recent advances in knowledge regarding the origins of this malignancy. An image of HG-SOC with reduced BRCA1 expression is featured on the cover (image by VM Howell). A major clinical issue for patients with HG-SOC is the development of therapy resistance. Five articles focus on therapy resistance and different ways to overcome resistance. Overall, this eBook is an outstanding resource to aid researchers design their programs of research and determine the most appropriate and up-to-date EOC model systems to address their research questions. Description based on e-publication, viewed on May 29, 2019. English Creative Commons Attribution 4.0 International CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode Unrestricted online access Ovaries Cancer Research. Neoplasms. Oncology. 3D-cell culture Ovarian cancer stem cells ovarian cancer tumor-associated macrophage BRCA chemoresistance fallopian tube tumour microenvironment mouse models of ovarian cancer patient derived xenografts primary ovarian tumour cells Ascites Howell, Viive Maarike, editor, contributor. Davidson, Ben, M.D., editor, contributor. Wang, Tian-Li, editor. Annunziata, C. (Christina) editor, contributor. Frontiers Research Foundation, issuing body. 2-88919-769-7 Frontiers in oncology. Frontiers research topics. |
language |
English |
format |
Electronic eBook |
author |
Ben Davidson |
spellingShingle |
Ben Davidson Advances in epithelial ovarian cancer model systems, microenvironmental influences, therapy, and origins / Frontiers Research Topics Frontiers in oncology |
author_facet |
Ben Davidson Howell, Viive Maarike, Davidson, Ben, M.D., Wang, Tian-Li, Annunziata, C. Frontiers Research Foundation, |
author_variant |
b d bd |
author2 |
Howell, Viive Maarike, Davidson, Ben, M.D., Wang, Tian-Li, Annunziata, C. Frontiers Research Foundation, |
author2_variant |
v m h vm vmh b d bd t l w tlw c a ca |
author2_fuller |
(Christina) |
author2_role |
TeilnehmendeR TeilnehmendeR TeilnehmendeR TeilnehmendeR TeilnehmendeR |
author_sort |
Ben Davidson |
title |
Advances in epithelial ovarian cancer model systems, microenvironmental influences, therapy, and origins / |
title_sub |
model systems, microenvironmental influences, therapy, and origins / |
title_full |
Advances in epithelial ovarian cancer [electronic resource] : model systems, microenvironmental influences, therapy, and origins / edited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata. |
title_fullStr |
Advances in epithelial ovarian cancer [electronic resource] : model systems, microenvironmental influences, therapy, and origins / edited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata. |
title_full_unstemmed |
Advances in epithelial ovarian cancer [electronic resource] : model systems, microenvironmental influences, therapy, and origins / edited by Viive Maarike Howell, Ben Davidson, Tian-Li Wang and Christina Annunziata. |
title_auth |
Advances in epithelial ovarian cancer model systems, microenvironmental influences, therapy, and origins / |
title_new |
Advances in epithelial ovarian cancer |
title_sort |
advances in epithelial ovarian cancer model systems, microenvironmental influences, therapy, and origins / |
series |
Frontiers Research Topics Frontiers in oncology |
series2 |
Frontiers Research Topics Frontiers in oncology |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2016 |
physical |
1 online resource (176 pages) : illustrations; digital, PDF file(s). |
isbn |
2-88919-769-7 |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
callnumber-label |
RC280 |
callnumber-sort |
RC 3280 O8 |
illustrated |
Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
616 - Diseases |
dewey-full |
616.99465 |
dewey-sort |
3616.99465 |
dewey-raw |
616.99465 |
dewey-search |
616.99465 |
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Advances in epithelial ovarian cancer model systems, microenvironmental influences, therapy, and origins / |
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