Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity
Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neur...
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Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (152 p.) |
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Michael A. Sutton auth Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity Frontiers Media SA 2016 1 electronic resource (152 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Activity within neural circuits shapes the synaptic properties of component neurons in a manner that maintains stable excitatory drive, a process referred to as homeostatic plasticity. These potent and adaptive mechanisms have been demonstrated to modulate activity at the level of an individual neuron, synapse, circuit, or entire network, and dysregulation at some or all of these levels may contribute to neuropsychiatric disorders, intellectual disability, and epilepsy. Greater mechanistic understanding of homeostatic plasticity will provide key insights into the etiology of these disorders, which may result from network instability and synaptic dysfunction. Over the past 15 years, the molecular mechanisms of this form of plasticity have been intensely studied in various model organisms, including invertebrates and vertebrates. Though once thought to have a predominantly postsynaptic basis, emerging evidence suggests that homeostatic mechanisms act on both sides of the synapse through mechanisms such as retrograde signaling, to orchestrate compensatory adaptations that maintain stable network function. These trans-synaptic signaling systems ultimately alter neurotransmitter release probability by a variety of mechanisms including changes in vesicle pool size and calcium influx. These adaptations are not expected to occur homogenously at all terminals of a pre-synaptic neuron, as they might synapse with neurons in non-overlapping circuits. However, the factors that govern the homeostatic control of synapse-specific plasticity are only beginning to be understood. In addition to our limited molecular understanding of pre-synaptic homeostatic plasticity, very little is known about its prevalence in vivo or its physiological and disease relevance. In this research topic, we aim to fill the aforementioned void by covering a broad range of topics that include: - Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations - The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking - Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals - Novel mechanisms of homeostatic adaptations in pre-synaptic neurons - Postsynaptic sensors of activity and retrograde synaptic signaling systems - A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types - Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations - How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity - Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders - Computational modeling of pre-synaptic homeostatic plasticity and network stability. English homeostatic plasticity retrograde signaling Neurological Disease Presynaptic adaptation neurotransmitter release 2-88919-704-2 Dion Dickman auth Jaichandar Subramanian auth |
language |
English |
format |
eBook |
author |
Michael A. Sutton |
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Michael A. Sutton Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity Frontiers Research Topics |
author_facet |
Michael A. Sutton Dion Dickman Jaichandar Subramanian |
author_variant |
m a s mas |
author2 |
Dion Dickman Jaichandar Subramanian |
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d d dd j s js |
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Michael A. Sutton |
title |
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
title_full |
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
title_fullStr |
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
title_full_unstemmed |
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
title_auth |
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
title_new |
Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
title_sort |
homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (152 p.) |
isbn |
2-88919-704-2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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n |
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(CKB)3710000000631051 (oapen)https://directory.doabooks.org/handle/20.500.12854/49519 (EXLCZ)993710000000631051 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
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Homeostatic and retrograde signaling mechanisms modulating presynaptic function and plasticity |
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Frontiers Research Topics |
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