30 years old : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / / edited by Tony Lefebvre and Tarik Issad.
Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and...
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Superior document: | Frontiers Research Topics |
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Place / Publishing House: | Switzerland : : Frontiers Media SA,, 2007-2015 |
Year of Publication: | 2015 2007 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (113 pages) :; illustrations. |
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Tarik Issad auth 30 years old [electronic resources] : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / edited by Tony Lefebvre and Tarik Issad. 30 years old Frontiers Media SA 2015 Switzerland : Frontiers Media SA, 2007-2015 1 online resource (113 pages) : illustrations. text txt rdacontent unmediated n rdamedia volume nc rdacarrier text file rda Frontiers Research Topics Includes bibliographical references. Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of "O-GlcNAc" by Gerald W. Hart. English Creative Commons NonCommercial-NoDerivs https://creativecommons.org/licenses/http://journal.frontiersin.org/researchtopic/2684/30-years-old-o-glcnac-reaches-age-of-reason---regulation-of-cell-signaling-and-metabolism-by-o-glcna Description based on online resource ; title from PDF title page (viewed on 01/19/2021) Unrestricted online access star Cell signalling Metabolism nutrition Hexosamine biosynthetic pathway O GlcNAcylation OGA Inflammation OGT Cell signaling epigenetics Cancer Lefebvre, Tony, editor. Isaad, Tarik, editor. |
language |
English |
format |
eBook |
author |
Tarik Issad |
spellingShingle |
Tarik Issad 30 years old O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / Frontiers Research Topics |
author_facet |
Tarik Issad Lefebvre, Tony, Isaad, Tarik, |
author_variant |
t i ti |
author2 |
Lefebvre, Tony, Isaad, Tarik, |
author2_variant |
t l tl t i ti |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Tarik Issad |
title |
30 years old O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / |
title_sub |
O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / |
title_full |
30 years old [electronic resources] : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / edited by Tony Lefebvre and Tarik Issad. |
title_fullStr |
30 years old [electronic resources] : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / edited by Tony Lefebvre and Tarik Issad. |
title_full_unstemmed |
30 years old [electronic resources] : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / edited by Tony Lefebvre and Tarik Issad. |
title_auth |
30 years old O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / |
title_alt |
30 years old |
title_new |
30 years old |
title_sort |
30 years old o-glcnac reaches age of reason - regulation of cell signaling and metabolism by o-glcnacylation / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 2007 |
physical |
1 online resource (113 pages) : illustrations. |
isbn |
9782889195916 (eboook) |
callnumber-first |
Q - Science |
callnumber-subject |
QP - Physiology |
callnumber-label |
QP702 |
callnumber-sort |
QP 3702 G577 |
illustrated |
Illustrated |
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500 - Science |
dewey-tens |
570 - Life sciences; biology |
dewey-ones |
572 - Biochemistry |
dewey-full |
572/.567 |
dewey-sort |
3572 3567 |
dewey-raw |
572/.567 |
dewey-search |
572/.567 |
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30 years old O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / |
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