HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies
Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarge...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2018 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (171 p.) |
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100 | 1 | |a Francesca Chiodi |4 auth | |
245 | 1 | 0 | |a HIV-Induced Damage of B Cells and Production of HIV Neutralizing Antibodies |
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490 | 1 | |a Frontiers Research Topics | |
520 | |a Multiple dysfunctions take place in the B cell compartment during HIV-1 infection, comprising depletion of resting memory B cells carrying serological memory to vaccines and previously met pathogens. In addition, population of B cells characterized by the expression of exhaustion markers are enlarged during HIV-1 infection. Antibodies with the capacity to neutralize a broad range of HIV-1 isolates can be detected only in a minority of infected patients, after a year or more from acute infection. An open question is whether the inability of producing neutralizing HIV-1 antibodies is somehow linked to the B cell immunopathology observed in patients. In this research topic we invited scientists to summarize the current state of knowledge on regulation and development of B cells and antibody responses during HIV-1 infection; fifteen contributions were received comprising both reviews and original articles. The articles are related to B cell dysfunctions identified in HIV-1 infected individuals, production of different types of antibodies (neutralizing versus non neutralizing, and of different isotypes) in vivo during HIV-1 infection and the biological factors which may impact on this process, clinical potential and applications of anti-HIV antibodies and how to achieve neutralizing antibody responses to HIV-1 epitopes upon vaccination. The topic has gathered articles on front-line research undertaken in the field of B cells and antibodies in HIV-1 infection. It is our hope that the collection of articles presented in this book may be useful for new and experienced scholars in the field and add a piece to the complex puzzle of knowledge needed for the development of an HIV-1 vaccine. | ||
546 | |a English | ||
653 | |a auto-antibodies to CCR5 | ||
653 | |a BAFF | ||
653 | |a Gene Expression | ||
653 | |a clinical potential of HIV-1 antibodies | ||
653 | |a mucosal IgA responses | ||
653 | |a FcRL4 | ||
653 | |a neutralizing and non neutralizing HIV-1 antibodies | ||
653 | |a HIV-1 vaccine targets | ||
653 | |a B cells | ||
653 | |a CXCL13 | ||
653 | |a maternal HIV antibodies | ||
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700 | 1 | |a Gabriella Scarlatti |4 auth | |
906 | |a BOOK | ||
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