Synaptic Assembly and Neural Circuit Development
Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the centra...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2018 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (191 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993548061504498 |
---|---|
ctrlnum |
(CKB)4920000000094182 (oapen)https://directory.doabooks.org/handle/20.500.12854/60393 (EXLCZ)994920000000094182 |
collection |
bib_alma |
record_format |
marc |
spelling |
Jaewon Ko auth Synaptic Assembly and Neural Circuit Development Frontiers Media SA 2018 1 electronic resource (191 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the central nervous system critically depends on the establishment of ‘precise’ synaptic connections between neurons and specific target cells. During synaptogenesis, synapses form, mature, stabilize, and are eliminated through processes that require intimate communication between pre- and postsynaptic partners. The sequential and/or parallel processes dictate the wiring of neural circuits in a rapid and dynamic fashion. Accumulating evidence suggests that activity-dependent synaptic and circuit plasticity reflects the assembly and disassembly of diverse synapses that occur in a distinctive manner in specific neuron types. In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations. English Synaptic adhesion molecule Neuron neural circuit assembly recognition synapse 2-88945-630-7 Chen Zhang auth |
language |
English |
format |
eBook |
author |
Jaewon Ko |
spellingShingle |
Jaewon Ko Synaptic Assembly and Neural Circuit Development Frontiers Research Topics |
author_facet |
Jaewon Ko Chen Zhang |
author_variant |
j k jk |
author2 |
Chen Zhang |
author2_variant |
c z cz |
author_sort |
Jaewon Ko |
title |
Synaptic Assembly and Neural Circuit Development |
title_full |
Synaptic Assembly and Neural Circuit Development |
title_fullStr |
Synaptic Assembly and Neural Circuit Development |
title_full_unstemmed |
Synaptic Assembly and Neural Circuit Development |
title_auth |
Synaptic Assembly and Neural Circuit Development |
title_new |
Synaptic Assembly and Neural Circuit Development |
title_sort |
synaptic assembly and neural circuit development |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2018 |
physical |
1 electronic resource (191 p.) |
isbn |
2-88945-630-7 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT jaewonko synapticassemblyandneuralcircuitdevelopment AT chenzhang synapticassemblyandneuralcircuitdevelopment |
status_str |
n |
ids_txt_mv |
(CKB)4920000000094182 (oapen)https://directory.doabooks.org/handle/20.500.12854/60393 (EXLCZ)994920000000094182 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Synaptic Assembly and Neural Circuit Development |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField |
_version_ |
1796648768785874945 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02816nam-a2200337z--4500</leader><controlfield tag="001">993548061504498</controlfield><controlfield tag="005">20231214133604.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2018 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)4920000000094182</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/60393</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)994920000000094182</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Jaewon Ko</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Synaptic Assembly and Neural Circuit Development</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (191 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the central nervous system critically depends on the establishment of ‘precise’ synaptic connections between neurons and specific target cells. During synaptogenesis, synapses form, mature, stabilize, and are eliminated through processes that require intimate communication between pre- and postsynaptic partners. The sequential and/or parallel processes dictate the wiring of neural circuits in a rapid and dynamic fashion. Accumulating evidence suggests that activity-dependent synaptic and circuit plasticity reflects the assembly and disassembly of diverse synapses that occur in a distinctive manner in specific neuron types. In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Synaptic adhesion molecule</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Neuron</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">neural circuit assembly</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">recognition</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">synapse</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88945-630-7</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen Zhang</subfield><subfield code="4">auth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:58:38 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2019-11-10 04:18:40 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338721000004498&Force_direct=true</subfield><subfield code="Z">5338721000004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338721000004498</subfield></datafield></record></collection> |