Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor
Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing recepto...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
Year of Publication: | 2018 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 electronic resource (189 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993548056104498 |
---|---|
ctrlnum |
(CKB)4920000000094138 (oapen)https://directory.doabooks.org/handle/20.500.12854/56243 (EXLCZ)994920000000094138 |
collection |
bib_alma |
record_format |
marc |
spelling |
Enikö Kallay auth Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor Frontiers Media SA 2018 1 electronic resource (189 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR. English proliferation and differentiation metastasis vitamin D G protein-coupled receptor (GPCR) crystal structure parathyroid hormone (PTH) cancer Alzheimer 2-88945-512-2 |
language |
English |
format |
eBook |
author |
Enikö Kallay |
spellingShingle |
Enikö Kallay Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor Frontiers Research Topics |
author_facet |
Enikö Kallay |
author_variant |
e k ek |
author_sort |
Enikö Kallay |
title |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
title_full |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
title_fullStr |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
title_full_unstemmed |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
title_auth |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
title_new |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
title_sort |
physiology and pathophysiology of the extracellular calcium-sensing receptor |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2018 |
physical |
1 electronic resource (189 p.) |
isbn |
2-88945-512-2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT enikokallay physiologyandpathophysiologyoftheextracellularcalciumsensingreceptor |
status_str |
n |
ids_txt_mv |
(CKB)4920000000094138 (oapen)https://directory.doabooks.org/handle/20.500.12854/56243 (EXLCZ)994920000000094138 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
container_title |
Frontiers Research Topics |
_version_ |
1787551946585931779 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02564nam-a2200361z--4500</leader><controlfield tag="001">993548056104498</controlfield><controlfield tag="005">20231214132839.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202102s2018 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)4920000000094138</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/56243</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)994920000000094138</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Enikö Kallay</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2018</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (189 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">proliferation and differentiation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">metastasis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">vitamin D</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">G protein-coupled receptor (GPCR)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">crystal structure</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">parathyroid hormone (PTH)</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cancer</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Alzheimer</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88945-512-2</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:33:42 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2019-11-10 04:18:40 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338719350004498&Force_direct=true</subfield><subfield code="Z">5338719350004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338719350004498</subfield></datafield></record></collection> |