Neuropsychopharmacology of psychosis: : relation of brain signals, cognition and chemistry / / topic editors: André Schmidt and Stefan Borgwardt.

• Superior document: Frontiers Research Topics
• Author: Andre Schmidt
• TeilnehmendeR: Schmidt, André,; Borgwardt, Stefan,; Frontiers Research Foundation,
• Place / Publishing House: [Lausanne, Switzerland] : : Frontiers Media SA,, 2015.; ©2015
• Year of Publication: 2015
• Language: English
• Series: Frontiers research topics.; Frontiers in psychiatry.
• Physical Description: 1 online resource (276 pages) :; illustrations; digitial file(s).
• Hierarchical level: Monograph
• Statement of Responsibility: topic editors: André Schmidt and Stefan Borgwardt.

Previous research over the past decades has identified diverse neurobiological underpinnings of psychosis. In particular, by combining a variety of different neuroimaging modalities, it has been shown that psychotic states and the actual transition phase from a clinical high-risk state to established psychosis is characterized by structural, functional and neurochemical changes across different brain regions.Further evidence revealed that maybe not only focal brain abnormalities are characteristic for psychosis but specifically also an abnormal functional integration among various brain areas. Some evidence also suggests that dysfunctional brain connectivity proceeds during the development of psychosis when subjects perform a cognitive task. Notably, altered brain connectivity during cognitive challenges was often found to be associated with psychopathological measures, suggesting a mechanistic relation between functional network integrity and the clinical expression of psychosis ... In this research topic, we like to cover the most recent neurobiological correlates for early stage psychosis and in particular for the prediction of psychosis by using different neurophysiological measures (e.g. structural and functional MRI, EEG, DTI or PET). Studies exploring effective connectivity or complex brain networks such as small-world properties with techniques like dynamic causal modelling, structural equation modelling, or graph theory analysis are highly appreciated. Very welcome are studies proving a link between clinical features such as psychopathology and cognition, brain signals, and chemistry (also in regard of antipsychotic treatments or substance-induced psychotic states). Moreover, environmental factors that may influence psychosis onset or its’ developmental processes will be brought together with a diversity of different research modalities. We also collect critical reviews, mini-reviews or theoretical reflections from leading international researcher and clinicians in this field. The purpose of our research topic is intended to provide a state-of-the-art cognitive perspective to consider developing psychosis, which might shed more lights into the pathophysiological and neurobiological mechanisms of psychosis.