Assessing Rare Variation in Complex Traits : Design and Analysis of Genetic Studies / / edited by Eleftheria Zeggini, Andrew Morris.
This unique volume is the first to cover a wide range of design and analysis issues in genetic studies of rare variants, with contributions from experts in the field, through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES. The book presents state-of-the-art met...
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| HerausgeberIn: | |
| Place / Publishing House: | New York, NY : : Springer New York :, Imprint: Springer,, 2015. |
| Year of Publication: | 2015 |
| Edition: | 1st ed. 2015. |
| Language: | English |
| Physical Description: | 1 online resource (262 p.) |
| Notes: | Description based upon print version of record. |
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Table of Contents:
- Calling Rare Variants from Genotype Data
- Calling Variants from Sequence Data
- Rare Variant Quality Control
- Rare Structural Variants
- Functional Annotation of Rare Genetic Variants
- The 1000 Genomes Project
- The UK10K Project
- Population Isolates
- Natural Selection at Rare Variants
- Collapsing Approaches for the Association Analysis of Rare Variants
- Rare Variant Association Analysis: Beyond Collapsing Approaches
- Significance Thresholds for Rare Variant Signals
- Power of Rare Variant Aggregate Tests
- Replicating Sequence-based Association Studies of Rare Variants
- Meta-analysis of Rare Variants
- Population Stratification of Rare Variants
- Use of Appropriate Controls in Rare Variant Studies
- Trans-ethnic Fine-mapping of Rare Causal Variants.