CD4+ T cell differentiation in infection : amendments to the Th1/Th2 axiom / / edited by Dragana Jankovic and Carl G. Feng.
CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory c...
Saved in:
: | |
---|---|
TeilnehmendeR: | |
Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 online resource (111 pages) :; colour illustrations. |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547756404498 |
---|---|
ctrlnum |
(CKB)3710000000569663 (SSID)ssj0001666247 (PQKBManifestationID)16455174 (PQKBTitleCode)TC0001666247 (PQKBWorkID)15000165 (PQKB)11743784 (WaSeSS)IndRDA00056289 (oapen)https://directory.doabooks.org/handle/20.500.12854/42835 (EXLCZ)993710000000569663 |
collection |
bib_alma |
record_format |
marc |
spelling |
Carl G Feng auth CD4+ T cell differentiation in infection [electronic resource] : amendments to the Th1/Th2 axiom / edited by Dragana Jankovic and Carl G. Feng. Frontiers Media SA 2015 France : Frontiers Media SA, 2015 1 online resource (111 pages) : colour illustrations. text txt computer c online resource cr text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph English Includes bibliographical references. CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections. Clinical Immunology HILCC Medicine HILCC Health & Biological Sciences HILCC Infection Dendritic Cells Cytokines Immunoregulation CD4 lymphocytes Memory long noncoding RNA Macrophages Metabolism Th1 Th2 Feng, Carl G. editor. Jankovic, Dragana editor. |
language |
English |
format |
Electronic eBook |
author |
Carl G Feng |
spellingShingle |
Carl G Feng CD4+ T cell differentiation in infection amendments to the Th1/Th2 axiom / Frontiers Research Topics |
author_facet |
Carl G Feng Feng, Carl G. Jankovic, Dragana |
author_variant |
c g f cgf |
author2 |
Feng, Carl G. Jankovic, Dragana |
author2_variant |
c g f cg cgf d j dj |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Carl G Feng |
title |
CD4+ T cell differentiation in infection amendments to the Th1/Th2 axiom / |
title_sub |
amendments to the Th1/Th2 axiom / |
title_full |
CD4+ T cell differentiation in infection [electronic resource] : amendments to the Th1/Th2 axiom / edited by Dragana Jankovic and Carl G. Feng. |
title_fullStr |
CD4+ T cell differentiation in infection [electronic resource] : amendments to the Th1/Th2 axiom / edited by Dragana Jankovic and Carl G. Feng. |
title_full_unstemmed |
CD4+ T cell differentiation in infection [electronic resource] : amendments to the Th1/Th2 axiom / edited by Dragana Jankovic and Carl G. Feng. |
title_auth |
CD4+ T cell differentiation in infection amendments to the Th1/Th2 axiom / |
title_new |
CD4+ T cell differentiation in infection |
title_sort |
cd4+ t cell differentiation in infection amendments to the th1/th2 axiom / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (111 pages) : colour illustrations. |
isbn |
9782889195657 (ebook) |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
callnumber-label |
RC582 |
callnumber-sort |
RC 3582 |
illustrated |
Illustrated |
work_keys_str_mv |
AT carlgfeng cd4tcelldifferentiationininfectionamendmentstotheth1th2axiom AT fengcarlg cd4tcelldifferentiationininfectionamendmentstotheth1th2axiom AT jankovicdragana cd4tcelldifferentiationininfectionamendmentstotheth1th2axiom |
status_str |
n |
ids_txt_mv |
(CKB)3710000000569663 (SSID)ssj0001666247 (PQKBManifestationID)16455174 (PQKBTitleCode)TC0001666247 (PQKBWorkID)15000165 (PQKB)11743784 (WaSeSS)IndRDA00056289 (oapen)https://directory.doabooks.org/handle/20.500.12854/42835 (EXLCZ)993710000000569663 |
carrierType_str_mv |
cr |
is_hierarchy_title |
CD4+ T cell differentiation in infection amendments to the Th1/Th2 axiom / |
author2_original_writing_str_mv |
noLinkedField noLinkedField |
_version_ |
1787548444567535617 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03692nam a2200577 i 4500</leader><controlfield tag="001">993547756404498</controlfield><controlfield tag="005">20230621135619.0</controlfield><controlfield tag="006">m o u </controlfield><controlfield tag="007">cr#|||||||||||</controlfield><controlfield tag="008">160829s2015 fr ad ob 000 | eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9782889195657 (ebook)</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000569663</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SSID)ssj0001666247</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBManifestationID)16455174</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBTitleCode)TC0001666247</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBWorkID)15000165</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKB)11743784</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(WaSeSS)IndRDA00056289</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/42835</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000569663</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">PQKB</subfield><subfield code="d">UkMaJRU</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">RC582</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Carl G Feng</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">CD4+ T cell differentiation in infection</subfield><subfield code="h">[electronic resource] :</subfield><subfield code="b">amendments to the Th1/Th2 axiom /</subfield><subfield code="c">edited by Dragana Jankovic and Carl G. Feng.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1="3" ind2="1"><subfield code="a">France :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (111 pages) :</subfield><subfield code="b">colour illustrations.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">text file</subfield><subfield code="2">rda</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Bibliographic Level Mode of Issuance: Monograph</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Clinical Immunology</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Medicine</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Health & Biological Sciences</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Infection</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Dendritic Cells</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Cytokines</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Immunoregulation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">CD4 lymphocytes</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Memory</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">long noncoding RNA</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Macrophages</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Metabolism</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Th1 Th2</subfield></datafield><datafield tag="700" ind1=" " ind2=" "><subfield code="a">Feng, Carl G.</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1=" " ind2=" "><subfield code="a">Jankovic, Dragana</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-06-25 10:43:01 Europe/Vienna</subfield><subfield code="d">00</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2016-01-23 20:51:17 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338629440004498&Force_direct=true</subfield><subfield code="Z">5338629440004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338629440004498</subfield></datafield></record></collection> |