Neural circuits underlying emotion and motivation : : insights from optogenetics and pharmacogenetics / / edited by Anton Ilango and Mary Kay Lobo.

Application of optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, feeding, arousal and motivated behaviors has provided crucial insights into brain function. Expression of light sensitive proteins into specific neurons and subsequent stimulation by light...

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Superior document:Frontiers Research Topics
:
TeilnehmendeR:
Place / Publishing House:France : : Frontiers Media SA,, 2015
Year of Publication:2015
Language:English
Series:Frontiers Research Topics.
Physical Description:1 online resource (172 pages) :; illustrations; digital file(s).
Notes:Bibliographic Level Mode of Issuance: Monograph
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Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo.
Frontiers Media SA 2015
France : Frontiers Media SA, 2015
1 online resource (172 pages) : illustrations; digital file(s).
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
text file rda
Frontiers Research Topics
Bibliographic Level Mode of Issuance: Monograph
English
Includes bibliographical references.
Application of optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, feeding, arousal and motivated behaviors has provided crucial insights into brain function. Expression of light sensitive proteins into specific neurons and subsequent stimulation by light (optogenetics) to control neuronal activity or expression of designer receptors exclusively activated by designer drugs (DREADD) in specific neuronal populations with subsequent activation or suppression of neuronal activity by an otherwise inert ligand (pharmacogenetics) provides control over defined elements of neural circuits. These novel tools have provided a more in depth understanding into several questions about brain function. These include:• Regulation of sleep-wake transition by the interaction of hypocretin neurons of lateral hypothalamus and nor adrenergic neurons of the locus coruleaus• Regulation of feeding by AGRP and POMC neurons in arcuate nucleus of the hypothalamus• Place preference and positive reinforcement by activation of DA neuron of VTA• Place aversion by activation of VTA GABA and lateral habenula neurons• Opposing influences on reinforcement by activation of D1 and D2 expressing medium spiny neurons of dorsal striatum and nucleus accumbensThe list still grows...From cell type specific manipulations to signaling properties in the cell (Dietz et al 2012) with unprecedented temporal resolution, these tools revolutionize the exploration of pathways/connectivity. Recent years also witnessed the extension of applying these tools from studying emotional valence and motivated behavior to reactivation of memory. c-fos based genetic approaches allowed us to integrate light sensitive opsins or DREADD receptor into specific neurons that are activated by certain learning events (for example fear) (Garner et al 2012; Liu et al 2012).In this Research Topic, we welcome researchers to contribute original research articles, review articles, methods and commentary on topics utilizing optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, motivation, reinforcement and memory. We believe the Research Topic will shine light on various questions we have about brain function by using novel optogenetic and pharmacogenetic tools and will hopefully inspire ongoing research to overcome the hurdles of using these tools to advance clinical applications.
Pharmacy, Therapeutics, & Pharmacology HILCC
Health & Biological Sciences HILCC
b Electronic books.
Pharmacogenetics
habits
Pain
emotion
Motivation
Addiction
Memory
optogenetics
Reinforcement
Lobo, Mary Kay editor.
Ilango, Anton editor.
Frontiers Research Topics.
language English
format eBook
author Mary Kay Lobo
spellingShingle Mary Kay Lobo
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics /
Frontiers Research Topics
author_facet Mary Kay Lobo
Lobo, Mary Kay
Ilango, Anton
author_variant m k l mkl
author2 Lobo, Mary Kay
Ilango, Anton
author2_variant m k l mk mkl
a i ai
author2_role TeilnehmendeR
TeilnehmendeR
author_sort Mary Kay Lobo
title Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics /
title_sub insights from optogenetics and pharmacogenetics /
title_full Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo.
title_fullStr Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo.
title_full_unstemmed Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo.
title_auth Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics /
title_new Neural circuits underlying emotion and motivation :
title_sort neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics /
series Frontiers Research Topics
series2 Frontiers Research Topics
publisher Frontiers Media SA
Frontiers Media SA,
publishDate 2015
physical 1 online resource (172 pages) : illustrations; digital file(s).
isbn 9782889195343
callnumber-first R - Medicine
callnumber-subject RM - Therapeutics and Pharmacology
callnumber-label RM301
callnumber-sort RM 3301.3 G45
genre b Electronic books.
genre_facet b Electronic books.
illustrated Illustrated
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