Neural circuits underlying emotion and motivation : : insights from optogenetics and pharmacogenetics / / edited by Anton Ilango and Mary Kay Lobo.
Application of optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, feeding, arousal and motivated behaviors has provided crucial insights into brain function. Expression of light sensitive proteins into specific neurons and subsequent stimulation by light...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
TeilnehmendeR: | |
Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics.
|
Physical Description: | 1 online resource (172 pages) :; illustrations; digital file(s). |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547716504498 |
---|---|
ctrlnum |
(CKB)3710000000526092 (SSID)ssj0001682834 (PQKBManifestationID)16508006 (PQKBTitleCode)TC0001682834 (PQKBWorkID)15037046 (PQKB)11097319 (WaSeSS)IndRDA00056611 (oapen)https://directory.doabooks.org/handle/20.500.12854/54471 (EXLCZ)993710000000526092 |
collection |
bib_alma |
record_format |
marc |
spelling |
Mary Kay Lobo auth Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo. Frontiers Media SA 2015 France : Frontiers Media SA, 2015 1 online resource (172 pages) : illustrations; digital file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph English Includes bibliographical references. Application of optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, feeding, arousal and motivated behaviors has provided crucial insights into brain function. Expression of light sensitive proteins into specific neurons and subsequent stimulation by light (optogenetics) to control neuronal activity or expression of designer receptors exclusively activated by designer drugs (DREADD) in specific neuronal populations with subsequent activation or suppression of neuronal activity by an otherwise inert ligand (pharmacogenetics) provides control over defined elements of neural circuits. These novel tools have provided a more in depth understanding into several questions about brain function. These include:• Regulation of sleep-wake transition by the interaction of hypocretin neurons of lateral hypothalamus and nor adrenergic neurons of the locus coruleaus• Regulation of feeding by AGRP and POMC neurons in arcuate nucleus of the hypothalamus• Place preference and positive reinforcement by activation of DA neuron of VTA• Place aversion by activation of VTA GABA and lateral habenula neurons• Opposing influences on reinforcement by activation of D1 and D2 expressing medium spiny neurons of dorsal striatum and nucleus accumbensThe list still grows...From cell type specific manipulations to signaling properties in the cell (Dietz et al 2012) with unprecedented temporal resolution, these tools revolutionize the exploration of pathways/connectivity. Recent years also witnessed the extension of applying these tools from studying emotional valence and motivated behavior to reactivation of memory. c-fos based genetic approaches allowed us to integrate light sensitive opsins or DREADD receptor into specific neurons that are activated by certain learning events (for example fear) (Garner et al 2012; Liu et al 2012).In this Research Topic, we welcome researchers to contribute original research articles, review articles, methods and commentary on topics utilizing optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, motivation, reinforcement and memory. We believe the Research Topic will shine light on various questions we have about brain function by using novel optogenetic and pharmacogenetic tools and will hopefully inspire ongoing research to overcome the hurdles of using these tools to advance clinical applications. Pharmacy, Therapeutics, & Pharmacology HILCC Health & Biological Sciences HILCC b Electronic books. Pharmacogenetics habits Pain emotion Motivation Addiction Memory optogenetics Reinforcement Lobo, Mary Kay editor. Ilango, Anton editor. Frontiers Research Topics. |
language |
English |
format |
eBook |
author |
Mary Kay Lobo |
spellingShingle |
Mary Kay Lobo Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / Frontiers Research Topics |
author_facet |
Mary Kay Lobo Lobo, Mary Kay Ilango, Anton |
author_variant |
m k l mkl |
author2 |
Lobo, Mary Kay Ilango, Anton |
author2_variant |
m k l mk mkl a i ai |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Mary Kay Lobo |
title |
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / |
title_sub |
insights from optogenetics and pharmacogenetics / |
title_full |
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo. |
title_fullStr |
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo. |
title_full_unstemmed |
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / edited by Anton Ilango and Mary Kay Lobo. |
title_auth |
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / |
title_new |
Neural circuits underlying emotion and motivation : |
title_sort |
neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (172 pages) : illustrations; digital file(s). |
isbn |
9782889195343 |
callnumber-first |
R - Medicine |
callnumber-subject |
RM - Therapeutics and Pharmacology |
callnumber-label |
RM301 |
callnumber-sort |
RM 3301.3 G45 |
genre |
b Electronic books. |
genre_facet |
b Electronic books. |
illustrated |
Illustrated |
work_keys_str_mv |
AT marykaylobo neuralcircuitsunderlyingemotionandmotivationinsightsfromoptogeneticsandpharmacogenetics AT lobomarykay neuralcircuitsunderlyingemotionandmotivationinsightsfromoptogeneticsandpharmacogenetics AT ilangoanton neuralcircuitsunderlyingemotionandmotivationinsightsfromoptogeneticsandpharmacogenetics |
status_str |
n |
ids_txt_mv |
(CKB)3710000000526092 (SSID)ssj0001682834 (PQKBManifestationID)16508006 (PQKBTitleCode)TC0001682834 (PQKBWorkID)15037046 (PQKB)11097319 (WaSeSS)IndRDA00056611 (oapen)https://directory.doabooks.org/handle/20.500.12854/54471 (EXLCZ)993710000000526092 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Neural circuits underlying emotion and motivation : insights from optogenetics and pharmacogenetics / |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField noLinkedField |
_version_ |
1796649024661487616 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>04374nam a2200577 i 4500</leader><controlfield tag="001">993547716504498</controlfield><controlfield tag="005">20230621135807.0</controlfield><controlfield tag="006">m o u </controlfield><controlfield tag="007">cr#||#||||||||</controlfield><controlfield tag="008">160829s2015 fr a o 000 | eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9782889195343</subfield><subfield code="q">(ebook)</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000526092</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SSID)ssj0001682834</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBManifestationID)16508006</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBTitleCode)TC0001682834</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBWorkID)15037046</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKB)11097319</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(WaSeSS)IndRDA00056611</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/54471</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000526092</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">PQKB</subfield><subfield code="b">eng</subfield><subfield code="d">UkMaJRU</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">RM301.3.G45</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mary Kay Lobo</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">Neural circuits underlying emotion and motivation :</subfield><subfield code="b">insights from optogenetics and pharmacogenetics /</subfield><subfield code="c">edited by Anton Ilango and Mary Kay Lobo.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1="3" ind2="1"><subfield code="a">France :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (172 pages) :</subfield><subfield code="b">illustrations; digital file(s).</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">text file</subfield><subfield code="2">rda</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Bibliographic Level Mode of Issuance: Monograph</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Application of optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, feeding, arousal and motivated behaviors has provided crucial insights into brain function. Expression of light sensitive proteins into specific neurons and subsequent stimulation by light (optogenetics) to control neuronal activity or expression of designer receptors exclusively activated by designer drugs (DREADD) in specific neuronal populations with subsequent activation or suppression of neuronal activity by an otherwise inert ligand (pharmacogenetics) provides control over defined elements of neural circuits. These novel tools have provided a more in depth understanding into several questions about brain function. These include:• Regulation of sleep-wake transition by the interaction of hypocretin neurons of lateral hypothalamus and nor adrenergic neurons of the locus coruleaus• Regulation of feeding by AGRP and POMC neurons in arcuate nucleus of the hypothalamus• Place preference and positive reinforcement by activation of DA neuron of VTA• Place aversion by activation of VTA GABA and lateral habenula neurons• Opposing influences on reinforcement by activation of D1 and D2 expressing medium spiny neurons of dorsal striatum and nucleus accumbensThe list still grows...From cell type specific manipulations to signaling properties in the cell (Dietz et al 2012) with unprecedented temporal resolution, these tools revolutionize the exploration of pathways/connectivity. Recent years also witnessed the extension of applying these tools from studying emotional valence and motivated behavior to reactivation of memory. c-fos based genetic approaches allowed us to integrate light sensitive opsins or DREADD receptor into specific neurons that are activated by certain learning events (for example fear) (Garner et al 2012; Liu et al 2012).In this Research Topic, we welcome researchers to contribute original research articles, review articles, methods and commentary on topics utilizing optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, motivation, reinforcement and memory. We believe the Research Topic will shine light on various questions we have about brain function by using novel optogenetic and pharmacogenetic tools and will hopefully inspire ongoing research to overcome the hurdles of using these tools to advance clinical applications.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmacy, Therapeutics, & Pharmacology</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Health & Biological Sciences</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="655" ind1=" " ind2="4"><subfield code="a">b Electronic books.</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Pharmacogenetics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">habits</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Pain</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">emotion</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Motivation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Addiction</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Memory</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">optogenetics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Reinforcement</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lobo, Mary Kay</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ilango, Anton</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Frontiers Research Topics.</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-08-08 05:39:24 Europe/Vienna</subfield><subfield code="d">00</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2015-12-12 16:57:58 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338657500004498&Force_direct=true</subfield><subfield code="Z">5338657500004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338657500004498</subfield></datafield></record></collection> |