ATP-gated P2X receptors in health and disease / topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin.
Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therape...
Saved in:
: | |
---|---|
TeilnehmendeR: | |
Place / Publishing House: | Lausanne, Switzerland : : Frontiers Media SA,, 2014. ©2014 |
Year of Publication: | 2015 2014 |
Language: | English |
Series: | Frontiers Research Topics
|
Physical Description: | 1 online resource (172 pages) :; illustrations, charts; digital, PDF file(s). |
Notes: |
|
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547715904498 |
---|---|
ctrlnum |
(CKB)3710000000526090 (SSID)ssj0001664966 (PQKBManifestationID)16454346 (PQKBTitleCode)TC0001664966 (PQKBWorkID)14999477 (PQKB)10870683 (WaSeSS)IndRDA00055876 (oapen)https://directory.doabooks.org/handle/20.500.12854/41518 (EXLCZ)993710000000526090 |
collection |
bib_alma |
record_format |
marc |
spelling |
Geoffrey Burnstock auth ATP-gated P2X receptors in health and disease [electronic resource] / topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin. Frontiers Media SA 2015 Lausanne, Switzerland : Frontiers Media SA, 2014. ©2014 1 online resource (172 pages) : illustrations, charts; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph Published in Frontiers in Cellular Neuroscience. Includes bibliographical references. Open access Unrestricted online access star Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases. English Neurology. Neurotransmitters. Medicine. Neurology HILCC Medicine HILCC Health & Biological Sciences HILCC Central Nervous System Ion Channels neurotransmitters P2X receptor ATP Khakh, Baljit S., editor. Nistri, Andrea, editor. Burnstock, Geoffrey, editor. Giniatullin, Rashid, editor. 2-88919-405-1 |
language |
English |
format |
Electronic eBook |
author |
Geoffrey Burnstock |
spellingShingle |
Geoffrey Burnstock ATP-gated P2X receptors in health and disease Frontiers Research Topics |
author_facet |
Geoffrey Burnstock Khakh, Baljit S., Nistri, Andrea, Burnstock, Geoffrey, Giniatullin, Rashid, |
author_variant |
g b gb |
author2 |
Khakh, Baljit S., Nistri, Andrea, Burnstock, Geoffrey, Giniatullin, Rashid, |
author2_variant |
b s k bs bsk a n an g b gb r g rg |
author2_role |
TeilnehmendeR TeilnehmendeR TeilnehmendeR TeilnehmendeR |
author_sort |
Geoffrey Burnstock |
title |
ATP-gated P2X receptors in health and disease |
title_full |
ATP-gated P2X receptors in health and disease [electronic resource] / topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin. |
title_fullStr |
ATP-gated P2X receptors in health and disease [electronic resource] / topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin. |
title_full_unstemmed |
ATP-gated P2X receptors in health and disease [electronic resource] / topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin. |
title_auth |
ATP-gated P2X receptors in health and disease |
title_new |
ATP-gated P2X receptors in health and disease |
title_sort |
atp-gated p2x receptors in health and disease |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 2014 |
physical |
1 online resource (172 pages) : illustrations, charts; digital, PDF file(s). |
isbn |
2-88919-405-1 |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
callnumber-label |
RC360 |
callnumber-sort |
RC 3360 |
illustrated |
Illustrated |
work_keys_str_mv |
AT geoffreyburnstock atpgatedp2xreceptorsinhealthanddisease AT khakhbaljits atpgatedp2xreceptorsinhealthanddisease AT nistriandrea atpgatedp2xreceptorsinhealthanddisease AT burnstockgeoffrey atpgatedp2xreceptorsinhealthanddisease AT giniatullinrashid atpgatedp2xreceptorsinhealthanddisease |
status_str |
c |
ids_txt_mv |
(CKB)3710000000526090 (SSID)ssj0001664966 (PQKBManifestationID)16454346 (PQKBTitleCode)TC0001664966 (PQKBWorkID)14999477 (PQKB)10870683 (WaSeSS)IndRDA00055876 (oapen)https://directory.doabooks.org/handle/20.500.12854/41518 (EXLCZ)993710000000526090 |
carrierType_str_mv |
cr |
is_hierarchy_title |
ATP-gated P2X receptors in health and disease |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField noLinkedField |
_version_ |
1796651924404043776 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03872cam a2200625 i 4500</leader><controlfield tag="001">993547715904498</controlfield><controlfield tag="005">20230622205852.0</controlfield><controlfield tag="006">m fs d </controlfield><controlfield tag="007">cr#mn#---|||||</controlfield><controlfield tag="008">160829s2014 xx ad o 000 0 eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000526090</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SSID)ssj0001664966</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBManifestationID)16454346</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBTitleCode)TC0001664966</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKBWorkID)14999477</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PQKB)10870683</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(WaSeSS)IndRDA00055876</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/41518</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000526090</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">PQKB</subfield><subfield code="d">UkMaJRU</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">RC360</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Geoffrey Burnstock</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">ATP-gated P2X receptors in health and disease</subfield><subfield code="h">[electronic resource] /</subfield><subfield code="c">topic editors Geoffrey Burnstock, Andrea Nistri, Baljit S. Khakh and Rashid Giniatullin.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Lausanne, Switzerland :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2014.</subfield></datafield><datafield tag="264" ind1=" " ind2="4"><subfield code="c">©2014</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (172 pages) :</subfield><subfield code="b">illustrations, charts; digital, PDF file(s).</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">text file</subfield><subfield code="2">rda</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Bibliographic Level Mode of Issuance: Monograph</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Published in Frontiers in Cellular Neuroscience.</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="506" ind1=" " ind2=" "><subfield code="a">Open access</subfield><subfield code="f">Unrestricted online access</subfield><subfield code="2">star</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Extracellular ATP is currently recognized as one of the most widely distributed neurotransmitters and neuromodulators in the peripheral and central nervous system. ATP-gated P2X receptors are expressed by neurons, glial and many other non-neuronal cells and represent an attractive target for therapeutic interventions. Diverse molecular and cellular mechanisms have been identified for P2X receptor functioning, including the ability to enlarge the size of the ion pore associated with the release of several key immune molecules. A major recent breakthrough was the determination of the X-ray crystal structures of zebrafish P2X4 receptor in ATP-bound and ATP-free states. The P2X receptor research field is rapidly growing, as evidenced by the almost 2000 papers published in the last 5 years. However, despite the fundamental signalling function of extracellular ATP in the nervous system, the widespread roles of P2X receptors have not been widely elucidated and presented in textbooks. In this volume of papers we aim to gather a collection of high quality papers, detailing the latest insights from the most accomplished international P2X receptor researchers. Importantly, basic research into P2X receptors has a strong translational impact and our collection of articles could be a valuable guide for the development of new pharmacological and biotechnological tools addressing the function of P2X receptors. Within this collection we plan to cover receptor structure-function relationships, receptors trafficking, to highlight the special properties of P2X receptors and their pharmacological profiles, and to describe the translational aspects of cellular ATP signaling in pain and in other neurological and vascular diseases.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Neurology.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Neurotransmitters.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Medicine.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Neurology</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Medicine</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Health & Biological Sciences</subfield><subfield code="2">HILCC</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Central Nervous System</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Ion Channels</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">neurotransmitters</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">P2X receptor</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">ATP</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Khakh, Baljit S.,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nistri, Andrea,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Burnstock, Geoffrey,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giniatullin, Rashid,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-405-1</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-06-27 07:04:59 Europe/Vienna</subfield><subfield code="d">00</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2015-12-12 16:57:58 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338657290004498&Force_direct=true</subfield><subfield code="Z">5338657290004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338657290004498</subfield></datafield></record></collection> |