Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors
Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (45 p.) |
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Atsuhiko Ichimura auth Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors Obesity and Diabetes Frontiers Media SA 2016 1 electronic resource (45 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors (FFARs) have been identified; GPR40/FFAR1, GPR119, and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain FFAs. GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain FFAs. These FFARs have come to be regarded as new drug targets for metabolic disorder such as obesity and type 2 diabetes, because a number of pharmacological and physiological studies have shown that these receptors are primarily involved in the energy metabolism in various tissues; insulin secretion, gastrointestinal hormone secretion, adipokine secretion, regulation of inflammation, regulation of autonomic nervous system, relation to gut microbiota, and so on. This Research Topic provides a comprehensive overview of the energy regulation by free fatty acid receptors and a new prospect for treatment of metabolic disorder such as obesity and type 2 diabetes. English microbiota Obesity GPCRs Insulin Resistance FFARs SCFAs free fatty acids Metabolism diabetes energy homeostasis 2-88919-747-6 Ikuo Kimura auth |
language |
English |
format |
eBook |
author |
Atsuhiko Ichimura |
spellingShingle |
Atsuhiko Ichimura Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors Frontiers Research Topics |
author_facet |
Atsuhiko Ichimura Ikuo Kimura |
author_variant |
a i ai |
author2 |
Ikuo Kimura |
author2_variant |
i k ik |
author_sort |
Atsuhiko Ichimura |
title |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
title_full |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
title_fullStr |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
title_full_unstemmed |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
title_auth |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
title_alt |
Obesity and Diabetes |
title_new |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
title_sort |
obesity and diabetes: energy regulation by free fatty acid receptors |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (45 p.) |
isbn |
2-88919-747-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT atsuhikoichimura obesityanddiabetesenergyregulationbyfreefattyacidreceptors AT ikuokimura obesityanddiabetesenergyregulationbyfreefattyacidreceptors AT atsuhikoichimura obesityanddiabetes AT ikuokimura obesityanddiabetes |
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n |
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(CKB)3710000000631116 (oapen)https://directory.doabooks.org/handle/20.500.12854/55086 (EXLCZ)993710000000631116 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
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1796651448534040576 |
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