Histamine in the brain / / topic editors Jian-Sheng Lin, Pertti Panula and Maria Beatrice Passani.
Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide differen...
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Place / Publishing House: | Switzerland : : Frontiers Media SA, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (99 pages) :; illustrations; digital, PDF file(s). |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
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Histamine in the brain / topic editors Jian-Sheng Lin, Pertti Panula and Maria Beatrice Passani. Frontiers Media SA 2015 Switzerland : Frontiers Media SA 2015 1 online resource (99 pages) : illustrations; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph Includes bibliographical references. Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive.This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.We encourage a range of contributions, from preclinical to clinical experimental approaches, theoretical perspectives, and research highlights. Of paramount importance will be the contribution of medicinal chemists that have provided the animal research field with selective histaminergic compounds and explained their receptor and intracellular mechanisms of action. English Histamine Receptors. Brain. anxiety cognition histamine receptors wakefulness heterogeneity Passani, Maria Beatrice editor. Lin, Jian-Sheng editor. Panula, Pertti, 1952- editor. |
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English |
format |
eBook |
author2 |
Passani, Maria Beatrice Lin, Jian-Sheng Panula, Pertti, 1952- |
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Passani, Maria Beatrice Lin, Jian-Sheng Panula, Pertti, 1952- |
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TeilnehmendeR TeilnehmendeR TeilnehmendeR |
title |
Histamine in the brain / |
spellingShingle |
Histamine in the brain / Frontiers Research Topics |
title_full |
Histamine in the brain / topic editors Jian-Sheng Lin, Pertti Panula and Maria Beatrice Passani. |
title_fullStr |
Histamine in the brain / topic editors Jian-Sheng Lin, Pertti Panula and Maria Beatrice Passani. |
title_full_unstemmed |
Histamine in the brain / topic editors Jian-Sheng Lin, Pertti Panula and Maria Beatrice Passani. |
title_auth |
Histamine in the brain / |
title_new |
Histamine in the brain / |
title_sort |
histamine in the brain / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2015 |
physical |
1 online resource (99 pages) : illustrations; digital, PDF file(s). |
isbn |
9782889194346 (ebook) |
callnumber-first |
Q - Science |
callnumber-subject |
QP - Physiology |
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QP801 |
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QP 3801 H5 |
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