Arrest chemokines / topic editor: Klaus Ley.
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized o...
Saved in:
Superior document: | Frontiers Research Topics |
---|---|
: | |
TeilnehmendeR: | |
Place / Publishing House: | [Lausanne, Switzerland] : : Frontiers Media SA,, 2015 ©2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers research topics.
Frontiers in immunology. |
Physical Description: | 1 online resource (108 pages) :; illustrations; digital, PDF file(s). |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547682404498 |
---|---|
ctrlnum |
(CKB)3710000000569674 (oapen)https://directory.doabooks.org/handle/20.500.12854/41301 (EXLCZ)993710000000569674 |
collection |
bib_alma |
record_format |
marc |
spelling |
Klaus Ley auth Arrest chemokines [electronic resource] / topic editor: Klaus Ley. Frontiers Media SA 2015 [Lausanne, Switzerland] : Frontiers Media SA, 2015 ©2015 1 online resource (108 pages) : illustrations; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file PDF rda Frontiers Research Topics Frontiers in Immunology Includes bibliographical references. Open access Unrestricted online access star Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparan sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial. Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. Here we present a series of ten reports that help clarify this crucial first step in the process of leukocyte transendothelial migration. English Chemokines Immunology. Immunologic diseases. Immunology. chemokine LFA-1 Signal Transduction Talin integrin leukocyte adhesion VLA-4 Kindlin-3 Ley, Klaus, 1957- editor, contributor. Frontiers Research Foundation, issuing body. 2-88919-430-2 Frontiers research topics. Frontiers in immunology. |
language |
English |
format |
Electronic eBook |
author |
Klaus Ley |
spellingShingle |
Klaus Ley Arrest chemokines Frontiers Research Topics Frontiers in Immunology |
author_facet |
Klaus Ley Ley, Klaus, 1957- Frontiers Research Foundation, |
author_variant |
k l kl |
author2 |
Ley, Klaus, 1957- Frontiers Research Foundation, |
author2_variant |
k l kl |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Klaus Ley |
title |
Arrest chemokines |
title_full |
Arrest chemokines [electronic resource] / topic editor: Klaus Ley. |
title_fullStr |
Arrest chemokines [electronic resource] / topic editor: Klaus Ley. |
title_full_unstemmed |
Arrest chemokines [electronic resource] / topic editor: Klaus Ley. |
title_auth |
Arrest chemokines |
title_new |
Arrest chemokines |
title_sort |
arrest chemokines |
series |
Frontiers Research Topics Frontiers in Immunology |
series2 |
Frontiers Research Topics Frontiers in Immunology |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (108 pages) : illustrations; digital, PDF file(s). |
isbn |
2-88919-430-2 |
illustrated |
Illustrated |
work_keys_str_mv |
AT klausley arrestchemokines AT leyklaus arrestchemokines AT frontiersresearchfoundation arrestchemokines |
status_str |
n |
ids_txt_mv |
(CKB)3710000000569674 (oapen)https://directory.doabooks.org/handle/20.500.12854/41301 (EXLCZ)993710000000569674 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics Frontiers in Immunology |
is_hierarchy_title |
Arrest chemokines |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
noLinkedField noLinkedField |
_version_ |
1796651448460640257 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02760nam a2200529 i 4500</leader><controlfield tag="001">993547682404498</controlfield><controlfield tag="005">20240221140643.0</controlfield><controlfield tag="006">a||||fo 000 0 </controlfield><controlfield tag="007">cr#mu#---uuuuu</controlfield><controlfield tag="008">160125t20152015sz ad||fob 000-0 eng|d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000569674</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/41301</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000569674</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="d">UkMaJRU</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Klaus Ley</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">Arrest chemokines</subfield><subfield code="h">[electronic resource] /</subfield><subfield code="c">topic editor: Klaus Ley.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">[Lausanne, Switzerland] :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1=" " ind2="4"><subfield code="c">©2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (108 pages) :</subfield><subfield code="b">illustrations; digital, PDF file(s).</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="347" ind1=" " ind2=" "><subfield code="a">text file</subfield><subfield code="b">PDF</subfield><subfield code="2">rda</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers Research Topics</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Frontiers in Immunology</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="506" ind1=" " ind2=" "><subfield code="a">Open access</subfield><subfield code="f">Unrestricted online access</subfield><subfield code="2">star</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparan sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial. Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. Here we present a series of ten reports that help clarify this crucial first step in the process of leukocyte transendothelial migration.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Chemokines</subfield><subfield code="x">Immunology.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Immunologic diseases.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Immunology.</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">chemokine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LFA-1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Signal Transduction</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Talin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">integrin</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">leukocyte adhesion</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">VLA-4</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Kindlin-3</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ley, Klaus,</subfield><subfield code="d">1957-</subfield><subfield code="e">editor, contributor.</subfield></datafield><datafield tag="710" ind1="2" ind2=" "><subfield code="a">Frontiers Research Foundation,</subfield><subfield code="e">issuing body.</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-430-2</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Frontiers research topics.</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Frontiers in immunology.</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2024-02-22 06:57:44 Europe/Vienna</subfield><subfield code="d">00</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2016-01-23 20:51:17 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338587310004498&Force_direct=true</subfield><subfield code="Z">5338587310004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338587310004498</subfield></datafield></record></collection> |