Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...

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Superior document:Frontiers Research Topics
:
Paolo Bonaldo
Luciano Merlini
Emanuele Marzetti
Year of Publication:2015
Language:English
Series:Frontiers Research Topics
Physical Description:1 electronic resource (248 p.)
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spelling Paolo Bonaldo auth
Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy
Frontiers Media SA 2015
1 electronic resource (248 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Frontiers Research Topics
Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.
English
Aging sarcopenia
muscular dystrophy
Mitochondrial dysfunction
therapy
skeletal muscle
Autophagy
Animal Models
Apoptosis
satellite cells
muscle imaging
2-88919-684-4
Luciano Merlini auth
Emanuele Marzetti auth
language English
format eBook
author Paolo Bonaldo
spellingShingle Paolo Bonaldo
Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
Frontiers Research Topics
author_facet Paolo Bonaldo
Luciano Merlini
Emanuele Marzetti
author_variant p b pb
author2 Luciano Merlini
Emanuele Marzetti
author2_variant l m lm
e m em
author_sort Paolo Bonaldo
title Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
title_full Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
title_fullStr Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
title_full_unstemmed Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
title_auth Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
title_alt Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy
title_new Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
title_sort pathophysiological mechanisms of sarcopenia in aging and in muscular dystrophy: a translational approach
series Frontiers Research Topics
series2 Frontiers Research Topics
publisher Frontiers Media SA
publishDate 2015
physical 1 electronic resource (248 p.)
isbn 2-88919-684-4
illustrated Not Illustrated
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AT emanuelemarzetti pathophysiologicalmechanismsofsarcopeniainagingandinmusculardystrophyatranslationalapproach
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