Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / / topic editor, Bruno Laugel.
T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex v...
Saved in:
: | |
---|---|
TeilnehmendeR: | |
Place / Publishing House: | [Lausanne, Switzerland] : : Frontiers Media SA,, 2014. |
Year of Publication: | 2015 2014 |
Language: | English |
Series: | Frontiers Research Topics,
|
Physical Description: | 1 online resource (191 pages). |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547678004498 |
---|---|
ctrlnum |
(CKB)3710000000526124 (WaSeSS)IndRDA00059232 (oapen)https://directory.doabooks.org/handle/20.500.12854/50630 (EXLCZ)993710000000526124 |
collection |
bib_alma |
record_format |
marc |
spelling |
Bruno Laugel auth Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / topic editor, Bruno Laugel. Frontiers Media SA 2015 [Lausanne, Switzerland] : Frontiers Media SA, 2014. 1 online resource (191 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics, 1664-8714 Includes bibliographical references. Description based on: online resource; title from pdf title page (frontiers, viewed Jul. 21, 2016). T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topics aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies. English T cells. T cells Recpetors. T-cells tcr Immunosuppression cancer immunotherapy pMHC 2-88919-413-2 Laugel, Bruno, editor. |
language |
English |
format |
eBook |
author |
Bruno Laugel |
spellingShingle |
Bruno Laugel Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / Frontiers Research Topics, |
author_facet |
Bruno Laugel Laugel, Bruno, |
author_variant |
b l bl |
author2 |
Laugel, Bruno, |
author2_variant |
b l bl |
author2_role |
TeilnehmendeR |
author_sort |
Bruno Laugel |
title |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / |
title_full |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / topic editor, Bruno Laugel. |
title_fullStr |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / topic editor, Bruno Laugel. |
title_full_unstemmed |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / topic editor, Bruno Laugel. |
title_auth |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / |
title_new |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / |
title_sort |
investigating and harnessing t-cell functions with engineered immune receptors and their ligands / |
series |
Frontiers Research Topics, |
series2 |
Frontiers Research Topics, |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 2014 |
physical |
1 online resource (191 pages). |
isbn |
2-88919-413-2 |
issn |
1664-8714 |
callnumber-first |
Q - Science |
callnumber-subject |
QR - Microbiology |
callnumber-label |
QR185 |
callnumber-sort |
QR 3185.8 T2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT brunolaugel investigatingandharnessingtcellfunctionswithengineeredimmunereceptorsandtheirligands AT laugelbruno investigatingandharnessingtcellfunctionswithengineeredimmunereceptorsandtheirligands |
status_str |
n |
ids_txt_mv |
(CKB)3710000000526124 (WaSeSS)IndRDA00059232 (oapen)https://directory.doabooks.org/handle/20.500.12854/50630 (EXLCZ)993710000000526124 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Investigating and harnessing T-cell functions with engineered immune receptors and their ligands / |
author2_original_writing_str_mv |
noLinkedField |
_version_ |
1796649033298608128 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01428nam a2200313 i 4500</leader><controlfield tag="001">993547678004498</controlfield><controlfield tag="005">20160721102219.0</controlfield><controlfield tag="006">m o u </controlfield><controlfield tag="007">cr |||||||||||</controlfield><controlfield tag="008">160721s2014 sz |||||o|||||||||||eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000526124</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(WaSeSS)IndRDA00059232</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/50630</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000526124</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">WaSeSS</subfield><subfield code="b">eng</subfield><subfield code="e">rda</subfield><subfield code="c">WaSeSS</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">QR185.8.T2</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bruno Laugel</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">Investigating and harnessing T-cell functions with engineered immune receptors and their ligands /</subfield><subfield code="c">topic editor, Bruno Laugel.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2015</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">[Lausanne, Switzerland] :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2014.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (191 pages).</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Frontiers Research Topics,</subfield><subfield code="x">1664-8714</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="588" ind1=" " ind2=" "><subfield code="a">Description based on: online resource; title from pdf title page (frontiers, viewed Jul. 21, 2016).</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topics aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">T cells.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">T cells</subfield><subfield code="x">Recpetors.</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">T-cells</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">tcr</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Immunosuppression</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cancer immunotherapy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pMHC</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-413-2</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Laugel, Bruno,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-02-22 20:25:46 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2015-12-12 16:57:58 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338615960004498&Force_direct=true</subfield><subfield code="Z">5338615960004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338615960004498</subfield></datafield></record></collection> |