Diverse functions of mucosal resident memory T cells / edited by Kimberly Sue Schluns and Kim Klonowski.
Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo...
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Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (86 pages) :; colour illustrations, charts. |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
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Kimberly Sue Schluns auth Diverse functions of mucosal resident memory T cells [electronic resource] / edited by Kimberly Sue Schluns and Kim Klonowski. Frontiers Media SA 2015 France : Frontiers Media SA, 2015 1 online resource (86 pages) : colour illustrations, charts. text txt computer c online resource cr text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph English Includes bibliographical references. Open Access Unrestricted online access star Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites. Microbiology & Immunology HILCC Biology HILCC Health & Biological Sciences HILCC Electronic books. pathogens Microscopy Migration Mucosa T cell differentiation Vaccination Inflammation Epithelium CD103 Schluns, Kimberly Sue editor. Klonowski, Kim editor. |
language |
English |
format |
Electronic eBook |
author |
Kimberly Sue Schluns |
spellingShingle |
Kimberly Sue Schluns Diverse functions of mucosal resident memory T cells Frontiers Research Topics |
author_facet |
Kimberly Sue Schluns Schluns, Kimberly Sue Klonowski, Kim |
author_variant |
k s s kss |
author2 |
Schluns, Kimberly Sue Klonowski, Kim |
author2_variant |
k s s ks kss k k kk |
author2_role |
TeilnehmendeR TeilnehmendeR |
author_sort |
Kimberly Sue Schluns |
title |
Diverse functions of mucosal resident memory T cells |
title_full |
Diverse functions of mucosal resident memory T cells [electronic resource] / edited by Kimberly Sue Schluns and Kim Klonowski. |
title_fullStr |
Diverse functions of mucosal resident memory T cells [electronic resource] / edited by Kimberly Sue Schluns and Kim Klonowski. |
title_full_unstemmed |
Diverse functions of mucosal resident memory T cells [electronic resource] / edited by Kimberly Sue Schluns and Kim Klonowski. |
title_auth |
Diverse functions of mucosal resident memory T cells |
title_new |
Diverse functions of mucosal resident memory T cells |
title_sort |
diverse functions of mucosal resident memory t cells |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (86 pages) : colour illustrations, charts. |
isbn |
9782889195398 (ebook) |
callnumber-first |
Q - Science |
callnumber-subject |
QR - Microbiology |
callnumber-label |
QR185 |
callnumber-sort |
QR 3185.8 T2 |
genre |
Electronic books. |
illustrated |
Illustrated |
work_keys_str_mv |
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