The Role of Glia in Plasticity and Behavior
Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in inve...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (104 p.) |
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Tycho Hoogland auth The Role of Glia in Plasticity and Behavior Frontiers Media SA 2015 1 electronic resource (104 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function. English Cerebellum C. elegans Astrocytes DREADD Cortex plasticity Gq Behavior glia Hippocampus 2-88919-690-9 Parpura, Vladimir, 1964- auth |
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English |
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author |
Tycho Hoogland |
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Tycho Hoogland The Role of Glia in Plasticity and Behavior Frontiers Research Topics |
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Tycho Hoogland Parpura, Vladimir, 1964- |
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author2 |
Parpura, Vladimir, 1964- |
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v p vp |
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Tycho Hoogland |
title |
The Role of Glia in Plasticity and Behavior |
title_full |
The Role of Glia in Plasticity and Behavior |
title_fullStr |
The Role of Glia in Plasticity and Behavior |
title_full_unstemmed |
The Role of Glia in Plasticity and Behavior |
title_auth |
The Role of Glia in Plasticity and Behavior |
title_new |
The Role of Glia in Plasticity and Behavior |
title_sort |
the role of glia in plasticity and behavior |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2015 |
physical |
1 electronic resource (104 p.) |
isbn |
2-88919-690-9 |
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Not Illustrated |
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AT tychohoogland theroleofgliainplasticityandbehavior AT parpuravladimir theroleofgliainplasticityandbehavior |
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Frontiers Research Topics |
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The Role of Glia in Plasticity and Behavior |
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Frontiers Research Topics |
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