Thyroid hormone in brain and brain cells
Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormo...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (106 p.) |
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Bernal, Juan auth Thyroid hormone in brain and brain cells Frontiers Media SA 2016 1 electronic resource (106 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation. English thyroid hormone neurodevelopment transporter nuclear receptor brain deiodinase 2-88919-702-6 Flamant, Frederic auth Koibuchi, Noriyuki auth |
language |
English |
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eBook |
author |
Bernal, Juan |
spellingShingle |
Bernal, Juan Thyroid hormone in brain and brain cells Frontiers Research Topics |
author_facet |
Bernal, Juan Flamant, Frederic Koibuchi, Noriyuki |
author_variant |
j b jb |
author2 |
Flamant, Frederic Koibuchi, Noriyuki |
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f f ff n k nk |
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Bernal, Juan |
title |
Thyroid hormone in brain and brain cells |
title_full |
Thyroid hormone in brain and brain cells |
title_fullStr |
Thyroid hormone in brain and brain cells |
title_full_unstemmed |
Thyroid hormone in brain and brain cells |
title_auth |
Thyroid hormone in brain and brain cells |
title_new |
Thyroid hormone in brain and brain cells |
title_sort |
thyroid hormone in brain and brain cells |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (106 p.) |
isbn |
2-88919-702-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT bernaljuan thyroidhormoneinbrainandbraincells AT flamantfrederic thyroidhormoneinbrainandbraincells AT koibuchinoriyuki thyroidhormoneinbrainandbraincells |
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(CKB)3710000000631082 (oapen)https://directory.doabooks.org/handle/20.500.12854/60915 (EXLCZ)993710000000631082 |
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Frontiers Research Topics |
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Thyroid hormone in brain and brain cells |
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Frontiers Research Topics |
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