The Origin of the Plasma Cell Heterogeneity
Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controver...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Thierry Defrance auth The Origin of the Plasma Cell Heterogeneity Frontiers Media SA 2015 1 electronic resource (80 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases. English IL21 Autoimmunity differentiation Cell Cycle B-cell Plasma cell Myeloma Autophagy B1 2-88919-734-4 Catherine Pellat-Deceunynck auth |
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Thierry Defrance |
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Thierry Defrance The Origin of the Plasma Cell Heterogeneity Frontiers Research Topics |
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Thierry Defrance Catherine Pellat-Deceunynck |
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Catherine Pellat-Deceunynck |
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Thierry Defrance |
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The Origin of the Plasma Cell Heterogeneity |
title_full |
The Origin of the Plasma Cell Heterogeneity |
title_fullStr |
The Origin of the Plasma Cell Heterogeneity |
title_full_unstemmed |
The Origin of the Plasma Cell Heterogeneity |
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The Origin of the Plasma Cell Heterogeneity |
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The Origin of the Plasma Cell Heterogeneity |
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the origin of the plasma cell heterogeneity |
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Frontiers Research Topics |
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Frontiers Research Topics |
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Frontiers Media SA |
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2015 |
physical |
1 electronic resource (80 p.) |
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2-88919-734-4 |
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Not Illustrated |
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AT thierrydefrance theoriginoftheplasmacellheterogeneity AT catherinepellatdeceunynck theoriginoftheplasmacellheterogeneity |
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(CKB)3710000000631061 (oapen)https://directory.doabooks.org/handle/20.500.12854/55432 (EXLCZ)993710000000631061 |
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Frontiers Research Topics |
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The Origin of the Plasma Cell Heterogeneity |
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