CD1- and MR1-restricted T cells in antimicrobial immunity / edited by S.M. Mansour Haeryfar and Thierry Mallevaey.
Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understandi...
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Superior document: | Frontiers Research Topics |
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Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2016 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (189 pages) :; colour illustrations. |
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S.M. Mansour Haeryfar auth CD1- and MR1-restricted T cells in antimicrobial immunity [electronic resource] / edited by S.M. Mansour Haeryfar and Thierry Mallevaey. Frontiers Media SA 2016 France : Frontiers Media SA, 2015 1 online resource (189 pages) : colour illustrations. text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Includes bibliographical references. Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic. English Cellular biology. CD1 MAIT cell infection immunopathology microbes inflammation innate-like T cells immunity NKT cell MR1 Thierry Mallevaey auth |
language |
English |
format |
Electronic eBook |
author |
S.M. Mansour Haeryfar |
spellingShingle |
S.M. Mansour Haeryfar CD1- and MR1-restricted T cells in antimicrobial immunity Frontiers Research Topics |
author_facet |
S.M. Mansour Haeryfar Thierry Mallevaey |
author_variant |
s m h smh |
author2 |
Thierry Mallevaey |
author2_variant |
t m tm |
author_sort |
S.M. Mansour Haeryfar |
title |
CD1- and MR1-restricted T cells in antimicrobial immunity |
title_full |
CD1- and MR1-restricted T cells in antimicrobial immunity [electronic resource] / edited by S.M. Mansour Haeryfar and Thierry Mallevaey. |
title_fullStr |
CD1- and MR1-restricted T cells in antimicrobial immunity [electronic resource] / edited by S.M. Mansour Haeryfar and Thierry Mallevaey. |
title_full_unstemmed |
CD1- and MR1-restricted T cells in antimicrobial immunity [electronic resource] / edited by S.M. Mansour Haeryfar and Thierry Mallevaey. |
title_auth |
CD1- and MR1-restricted T cells in antimicrobial immunity |
title_new |
CD1- and MR1-restricted T cells in antimicrobial immunity |
title_sort |
cd1- and mr1-restricted t cells in antimicrobial immunity |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2016 2015 |
physical |
1 online resource (189 pages) : colour illustrations. |
isbn |
9782889197507 (ebook) |
illustrated |
Illustrated |
work_keys_str_mv |
AT smmansourhaeryfar cd1andmr1restrictedtcellsinantimicrobialimmunity AT thierrymallevaey cd1andmr1restrictedtcellsinantimicrobialimmunity |
status_str |
c |
ids_txt_mv |
(CKB)3710000000631130 (oapen)https://directory.doabooks.org/handle/20.500.12854/42834 (EXLCZ)993710000000631130 |
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cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
CD1- and MR1-restricted T cells in antimicrobial immunity |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
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