The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance

The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance

The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mT...

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Superior document:Frontiers Research Topics
:
Geraldo Aleixo Passos
Ernna Herida Oliveira
Daniella Areas Mendes-da-Cruz
Year of Publication:2016
Language:English
Series:Frontiers Research Topics
Physical Description:1 electronic resource (107 p.)
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spelling Geraldo Aleixo Passos auth
The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
Frontiers Media SA 2016
1 electronic resource (107 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Frontiers Research Topics
The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte–TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell development, chemokines and migration of T cells, miRNAs and the thymic atrophy, cell–cell interactions, and thymus ontogeny. Authors raised hypothesis, discuss concepts, and show open questions. The remaining important issues to resolve questions within the central tolerance research are briefly discussed below.
English
thymic crosstalk
Central Tolerance
promiscuous gene expression
Aire gene
cell-cell interaction
thymocyte
microRNA
Thymic B cell
Chemokines
Thymus
2-88919-770-0
Ernna Herida Oliveira auth
Daniella Areas Mendes-da-Cruz auth
language English
format eBook
author Geraldo Aleixo Passos
spellingShingle Geraldo Aleixo Passos
The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
Frontiers Research Topics
author_facet Geraldo Aleixo Passos
Ernna Herida Oliveira
Daniella Areas Mendes-da-Cruz
author_variant g a p gap
author2 Ernna Herida Oliveira
Daniella Areas Mendes-da-Cruz
author2_variant e h o eho
d a m d damd
author_sort Geraldo Aleixo Passos
title The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
title_full The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
title_fullStr The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
title_full_unstemmed The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
title_auth The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
title_new The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance
title_sort the role of aire, micrornas and cell-cell interactions on thymic architecture and induction of tolerance
series Frontiers Research Topics
series2 Frontiers Research Topics
publisher Frontiers Media SA
publishDate 2016
physical 1 electronic resource (107 p.)
isbn 2-88919-770-0
illustrated Not Illustrated
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