Mechanisms in parkinson's disease : : models and treatments / / Juliana Dushanova, editor.
Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key...
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Place / Publishing House: | [Place of publication not identified] : : InTech,, [2012] ©2012 |
Year of Publication: | 2012 |
Language: | English |
Physical Description: | 1 online resource (606 pages) :; illustrations |
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(CKB)3230000000076391 (NjHacI)993230000000076391 (oapen)https://directory.doabooks.org/handle/20.500.12854/65532 (EXLCZ)993230000000076391 |
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Dushanova, Juliana edt Mechanisms in parkinson's disease : models and treatments / Juliana Dushanova, editor. Mechanisms in parkinson's disease IntechOpen 2012 [Place of publication not identified] : InTech, [2012] ©2012 1 online resource (606 pages) : illustrations text txt rdacontent computer c rdamedia online resource cr rdacarrier Description based on: online resource; title from PDF information screen (InTech, viewed October 13, 2022). Includes bibliographical references. Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process. English Parkinson's disease Chemotherapy. Neurology & clinical neurophysiology 953-307-876-6 Dushanova, Juliana, editor. |
language |
English |
format |
eBook |
author2 |
Dushanova, Juliana, |
author_facet |
Dushanova, Juliana, |
author2_variant |
j d jd j d jd |
author2_role |
TeilnehmendeR |
title |
Mechanisms in parkinson's disease : models and treatments / |
spellingShingle |
Mechanisms in parkinson's disease : models and treatments / |
title_sub |
models and treatments / |
title_full |
Mechanisms in parkinson's disease : models and treatments / Juliana Dushanova, editor. |
title_fullStr |
Mechanisms in parkinson's disease : models and treatments / Juliana Dushanova, editor. |
title_full_unstemmed |
Mechanisms in parkinson's disease : models and treatments / Juliana Dushanova, editor. |
title_auth |
Mechanisms in parkinson's disease : models and treatments / |
title_alt |
Mechanisms in parkinson's disease |
title_new |
Mechanisms in parkinson's disease : |
title_sort |
mechanisms in parkinson's disease : models and treatments / |
publisher |
IntechOpen InTech, |
publishDate |
2012 |
physical |
1 online resource (606 pages) : illustrations |
isbn |
953-51-6741-3 953-307-876-6 |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
callnumber-label |
RC382 |
callnumber-sort |
RC 3382 M434 42012 |
illustrated |
Illustrated |
dewey-hundreds |
600 - Technology |
dewey-tens |
610 - Medicine & health |
dewey-ones |
616 - Diseases |
dewey-full |
616.8 |
dewey-sort |
3616.8 |
dewey-raw |
616.8 |
dewey-search |
616.8 |
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AT dushanovajuliana mechanismsinparkinsonsdiseasemodelsandtreatments AT dushanovajuliana mechanismsinparkinsonsdisease |
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Mechanisms in parkinson's disease : models and treatments / |
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