DNA helicases : expression, functions and clinical implications / / topic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro Furuichi.
Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-repl...
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Place / Publishing House: | France : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (78 pages) :; illustrations, colour charts. |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
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Fumiaki Uchiumi auth DNA helicases [electronic resource] : expression, functions and clinical implications / topic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro Furuichi. Frontiers Media SA 2015 France : Frontiers Media SA, 2015 1 online resource (78 pages) : illustrations, colour charts. text txt computer c online resource cr text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph English Includes bibliographical references. Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases. Animal Biochemistry HILCC Human Anatomy & Physiology HILCC Health & Biological Sciences HILCC DNA Repair Aging helicases Telomere Cancer Furuichi, Yasuhiro editor. Uchiumi, Fumiaki editor. Seki, Masayuki editor. |
language |
English |
format |
Electronic eBook |
author |
Fumiaki Uchiumi |
spellingShingle |
Fumiaki Uchiumi DNA helicases expression, functions and clinical implications / Frontiers Research Topics |
author_facet |
Fumiaki Uchiumi Furuichi, Yasuhiro Uchiumi, Fumiaki Seki, Masayuki |
author_variant |
f u fu |
author2 |
Furuichi, Yasuhiro Uchiumi, Fumiaki Seki, Masayuki |
author2_variant |
y f yf f u fu m s ms |
author2_role |
TeilnehmendeR TeilnehmendeR TeilnehmendeR |
author_sort |
Fumiaki Uchiumi |
title |
DNA helicases expression, functions and clinical implications / |
title_sub |
expression, functions and clinical implications / |
title_full |
DNA helicases [electronic resource] : expression, functions and clinical implications / topic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro Furuichi. |
title_fullStr |
DNA helicases [electronic resource] : expression, functions and clinical implications / topic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro Furuichi. |
title_full_unstemmed |
DNA helicases [electronic resource] : expression, functions and clinical implications / topic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro Furuichi. |
title_auth |
DNA helicases expression, functions and clinical implications / |
title_new |
DNA helicases |
title_sort |
dna helicases expression, functions and clinical implications / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (78 pages) : illustrations, colour charts. |
isbn |
9782889195756 (ebook) |
callnumber-first |
Q - Science |
callnumber-subject |
QP - Physiology |
callnumber-label |
QP616 |
callnumber-sort |
QP 3616 D54 |
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