Never-resting microglia : physiological roles in the healthy brain and pathological implications
Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveri...
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Place / Publishing House: | [Place of publication not identified] : Frontiers Media SA, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics,
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Physical Description: | 1 online resource (172 pages). |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
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Never-resting microglia : physiological roles in the healthy brain and pathological implications [Place of publication not identified] Frontiers Media SA 2015 1 online resource (172 pages). text txt computer c online resource cr Frontiers Research Topics, 1664-8714 Bibliographic Level Mode of Issuance: Monograph English Includes bibliographical references. Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic will review the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic will discuss the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the maintenance of the blood brain barrier; the regulation of adult neurogenesis and hippocampal learning; and neuronal survival, among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic will also summarize the current view of microglial nomenclature, phenotypes, origin and differentiation, sex differences, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state will be discussed. In conclusion, this Research Topic seeks to emphasize how the current research in neuroscience is challenged by never-resting microglia. Neuroscience HILCC Human Anatomy & Physiology HILCC Health & Biological Sciences HILCC Sierra, Amanda Contributor Wake, Hiroaki Contributor Tremblay, Marie-Ève Contributor |
language |
English |
format |
eBook |
author2 |
Sierra, Amanda Wake, Hiroaki Tremblay, Marie-Ève |
author_facet |
Sierra, Amanda Wake, Hiroaki Tremblay, Marie-Ève |
author2_variant |
a s as h w hw m è t mèt |
author2_role |
TeilnehmendeR TeilnehmendeR TeilnehmendeR |
title |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
spellingShingle |
Never-resting microglia : physiological roles in the healthy brain and pathological implications Frontiers Research Topics, |
title_full |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
title_fullStr |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
title_full_unstemmed |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
title_auth |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
title_new |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
title_sort |
never-resting microglia : physiological roles in the healthy brain and pathological implications |
series |
Frontiers Research Topics, |
series2 |
Frontiers Research Topics, |
publisher |
Frontiers Media SA |
publishDate |
2015 |
physical |
1 online resource (172 pages). |
issn |
1664-8714 |
callnumber-first |
Q - Science |
callnumber-subject |
QP - Physiology |
callnumber-label |
QP363 |
callnumber-sort |
QP 3363.2 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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is_hierarchy_title |
Never-resting microglia : physiological roles in the healthy brain and pathological implications |
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