The role of viable but non-infectious developmental forms in chlamydial biology / / topic editors, Nicole Borel, Andreas Pospischil, Alan P. Hudson, Jan Rupp and Robert V. Schoborg.
The chlamydiae are Gram-negative, obligate intracellular bacteria with a complex developmental cycle comprising a metabolically less-active, infectious stage, the elementary body (EB), and a metabolically more active stage, the reticulate body (RB). They are responsible for many acute and chronic di...
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Place / Publishing House: | [Lausanne, Switzerland] : : Frontiers Media SA,, 2014. |
Year of Publication: | 2014 |
Language: | English |
Series: | Frontiers Research Topics,
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Physical Description: | 1 online resource (119 pages). |
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Alan Paul Hudson auth The role of viable but non-infectious developmental forms in chlamydial biology / topic editors, Nicole Borel, Andreas Pospischil, Alan P. Hudson, Jan Rupp and Robert V. Schoborg. Frontiers Media SA 2014 [Lausanne, Switzerland] : Frontiers Media SA, 2014. 1 online resource (119 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics, 1664-8714 Includes bibliographical references. Description based on: online resource; title from pdf title page (frontiers, viewed Jun. 21, 2016). The chlamydiae are Gram-negative, obligate intracellular bacteria with a complex developmental cycle comprising a metabolically less-active, infectious stage, the elementary body (EB), and a metabolically more active stage, the reticulate body (RB). They are responsible for many acute and chronic diseases in humans and animals. In order to play a causative role in chronic diseases, chlamydiae would need to persist and to re-activate within infected cells/tissues for extended periods of time. Persistence in vitro is defined as viable but non-cultivable chlamydiae involving morphologically enlarged, aberrant, and nondividing RBs, termed aberrant bodies (AB). In vitro, alterations of the normal developmental cycle of chlamydiae can be induced by the addition of Interferon-? (IFN-?), tumor necrosis factor-a (TNF-a) and penicillin G exposure as well as amino acid or iron deprivation, monocyte infection and co-infection with viruses. In vivo, key questions include whether or not ABs occur in infected patients and animals and whether such ABs can contribute to prolonged, chronic inflammation, fibrosis, and scarring through continuing stimulation of the host immune system known from diseases such as trachoma, pelvic inflammatory disease, reactive arthritis and atherosclerosis. To date, the direct causal role in the pathogenesis of chlamydial infection and persistence in vivo has been questioned since there was no tractable animal model of chlamydial persistence so far. A very recent study was able to establish an experimental animal model of in vivo persistence, when C. muridarum vaginally-infected mice were gavaged with amoxicillin. Amoxicillin treatment induced C. muridarum to enter the persistent state in vivo. Recent in vivo data from patients indicate that viable but non-infectious developmental stages are present in the genital tract of chronically-infected women and that the gastrointestinal tract might be a reservoir for persistent chlamydial infections at other sites. English Chlamydia infections. stress response chlamydia Chronic Disease 2-88919-321-7 Borel, Nicole, editor. Pospischil, Andreas, editor. Hudson, Alan P., editor. Rupp, Jan, editor. Schoborg, Robert V, editor. |
language |
English |
format |
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author |
Alan Paul Hudson |
spellingShingle |
Alan Paul Hudson The role of viable but non-infectious developmental forms in chlamydial biology / Frontiers Research Topics, |
author_facet |
Alan Paul Hudson Borel, Nicole, Pospischil, Andreas, Hudson, Alan P., Rupp, Jan, Schoborg, Robert V, |
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Borel, Nicole, Pospischil, Andreas, Hudson, Alan P., Rupp, Jan, Schoborg, Robert V, |
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TeilnehmendeR TeilnehmendeR TeilnehmendeR TeilnehmendeR TeilnehmendeR |
author_sort |
Alan Paul Hudson |
title |
The role of viable but non-infectious developmental forms in chlamydial biology / |
title_full |
The role of viable but non-infectious developmental forms in chlamydial biology / topic editors, Nicole Borel, Andreas Pospischil, Alan P. Hudson, Jan Rupp and Robert V. Schoborg. |
title_fullStr |
The role of viable but non-infectious developmental forms in chlamydial biology / topic editors, Nicole Borel, Andreas Pospischil, Alan P. Hudson, Jan Rupp and Robert V. Schoborg. |
title_full_unstemmed |
The role of viable but non-infectious developmental forms in chlamydial biology / topic editors, Nicole Borel, Andreas Pospischil, Alan P. Hudson, Jan Rupp and Robert V. Schoborg. |
title_auth |
The role of viable but non-infectious developmental forms in chlamydial biology / |
title_new |
The role of viable but non-infectious developmental forms in chlamydial biology / |
title_sort |
the role of viable but non-infectious developmental forms in chlamydial biology / |
series |
Frontiers Research Topics, |
series2 |
Frontiers Research Topics, |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2014 |
physical |
1 online resource (119 pages). |
isbn |
2-88919-321-7 |
issn |
1664-8714 |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
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RC124 |
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RC 3124.5 |
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Not Illustrated |
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