Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / / topic editors, Raimond L. Winslow, Jennie Larkin and Pankaj Qasba.
Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both...
Saved in:
: | |
---|---|
TeilnehmendeR: | |
Place / Publishing House: | [Lausanne, Switzerland] : : Frontiers Media SA,, 2014. |
Year of Publication: | 2014 |
Language: | English |
Series: | Frontiers Research Topics,
|
Physical Description: | 1 online resource (180 pages). |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993547151304498 |
---|---|
ctrlnum |
(CKB)3710000000504579 (WaSeSS)IndRDA00058608 (oapen)https://directory.doabooks.org/handle/20.500.12854/60440 (EXLCZ)993710000000504579 |
collection |
bib_alma |
record_format |
marc |
spelling |
Pankaj Qasba auth Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / topic editors, Raimond L. Winslow, Jennie Larkin and Pankaj Qasba. Frontiers Media SA 2014 [Lausanne, Switzerland] : Frontiers Media SA, 2014. 1 online resource (180 pages). text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics, 1664-8714 Includes bibliographical references. Description based on: online resource; title from pdf title page (frontiers, viewed Jun. 29, 2016). Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding. This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations. The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders. This Research Topic will be of great interest to the cardiovascular research community as well as to the general community of systems biologists. English Sleep disorders Treatment. Heart Treatment. Lungs Treatment. Blood Treatment. sepsis models immune system models micro-RNA networks pulmonary models Computational Medicine cardiac models 2-88919-249-0 Winslow, Raimond L., editor. Larkin, Jennie, editor. Qasba, Pankaj, editor. |
language |
English |
format |
eBook |
author |
Pankaj Qasba |
spellingShingle |
Pankaj Qasba Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / Frontiers Research Topics, |
author_facet |
Pankaj Qasba Winslow, Raimond L., Larkin, Jennie, Qasba, Pankaj, |
author_variant |
p q pq |
author2 |
Winslow, Raimond L., Larkin, Jennie, Qasba, Pankaj, |
author2_variant |
r l w rl rlw j l jl p q pq |
author2_role |
TeilnehmendeR TeilnehmendeR TeilnehmendeR |
author_sort |
Pankaj Qasba |
title |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / |
title_full |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / topic editors, Raimond L. Winslow, Jennie Larkin and Pankaj Qasba. |
title_fullStr |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / topic editors, Raimond L. Winslow, Jennie Larkin and Pankaj Qasba. |
title_full_unstemmed |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / topic editors, Raimond L. Winslow, Jennie Larkin and Pankaj Qasba. |
title_auth |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / |
title_new |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / |
title_sort |
systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / |
series |
Frontiers Research Topics, |
series2 |
Frontiers Research Topics, |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2014 |
physical |
1 online resource (180 pages). |
isbn |
2-88919-249-0 |
issn |
1664-8714 |
callnumber-first |
R - Medicine |
callnumber-subject |
RC - Internal Medicine |
callnumber-label |
RC547 |
callnumber-sort |
RC 3547 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT pankajqasba systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders AT winslowraimondl systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders AT larkinjennie systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders AT qasbapankaj systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders |
status_str |
n |
ids_txt_mv |
(CKB)3710000000504579 (WaSeSS)IndRDA00058608 (oapen)https://directory.doabooks.org/handle/20.500.12854/60440 (EXLCZ)993710000000504579 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders / |
author2_original_writing_str_mv |
noLinkedField noLinkedField noLinkedField |
_version_ |
1787548463477555200 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01666nam a2200361 i 4500</leader><controlfield tag="001">993547151304498</controlfield><controlfield tag="005">20160629094411.0</controlfield><controlfield tag="006">m o u </controlfield><controlfield tag="007">cr |||||||||||</controlfield><controlfield tag="008">160629s2014 sz |||||o|||||||||||eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)3710000000504579</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(WaSeSS)IndRDA00058608</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/60440</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)993710000000504579</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">WaSeSS</subfield><subfield code="b">eng</subfield><subfield code="e">rda</subfield><subfield code="c">WaSeSS</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="4"><subfield code="a">RC547</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Pankaj Qasba</subfield><subfield code="4">auth</subfield></datafield><datafield tag="245" ind1="0" ind2="0"><subfield code="a">Systems biology approaches to understanding the cause and treatment of heart, lung, blood, and sleep disorders /</subfield><subfield code="c">topic editors, Raimond L. Winslow, Jennie Larkin and Pankaj Qasba.</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="b">Frontiers Media SA</subfield><subfield code="c">2014</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">[Lausanne, Switzerland] :</subfield><subfield code="b">Frontiers Media SA,</subfield><subfield code="c">2014.</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (180 pages).</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Frontiers Research Topics,</subfield><subfield code="x">1664-8714</subfield></datafield><datafield tag="504" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references.</subfield></datafield><datafield tag="588" ind1=" " ind2=" "><subfield code="a">Description based on: online resource; title from pdf title page (frontiers, viewed Jun. 29, 2016).</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding. This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations. The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders. This Research Topic will be of great interest to the cardiovascular research community as well as to the general community of systems biologists.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Sleep disorders</subfield><subfield code="x">Treatment.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Heart</subfield><subfield code="x">Treatment.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Lungs</subfield><subfield code="x">Treatment.</subfield></datafield><datafield tag="650" ind1=" " ind2="0"><subfield code="a">Blood</subfield><subfield code="x">Treatment.</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">sepsis models</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">immune system models</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">micro-RNA networks</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">pulmonary models</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Computational Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cardiac models</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">2-88919-249-0</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Winslow, Raimond L.,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Larkin, Jennie,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Qasba, Pankaj,</subfield><subfield code="e">editor.</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-02-22 20:09:33 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2015-11-22 13:16:40 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338427950004498&Force_direct=true</subfield><subfield code="Z">5338427950004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338427950004498</subfield></datafield></record></collection> |