Manipulation of the host cell by viral auxiliary proteins / / topic editors Nadine Laguette and Monsef Benkirane.
Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of...
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Place / Publishing House: | Switzerland : : Frontiers Media SA,, 2015 |
Year of Publication: | 2015 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 online resource (118 pages) :; illustrations; digital, PDF file(s). |
Notes: | Bibliographic Level Mode of Issuance: Monograph |
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Nadine Laguette auth Manipulation of the host cell by viral auxiliary proteins / topic editors Nadine Laguette and Monsef Benkirane. Frontiers Media SA 2015 Switzerland : Frontiers Media SA, 2015 1 online resource (118 pages) : illustrations; digital, PDF file(s). text txt rdacontent computer c rdamedia online resource cr rdacarrier text file rda Frontiers Research Topics Bibliographic Level Mode of Issuance: Monograph Includes bibliographical references. Productive HIV infection requires completion of all the steps of the replication cycle, the success of which largely relying on the multiple interactions established by viral proteins with cellular partners. Indeed, cellular and viral fates are intertwined and this interplay may involve rerouting of cellular factors/pathways to the benefit of the viral life cycle. To gain a foothold into host cells, HIV has to take advantage of available cellular factories and overcome the numerous potential blocks opposed to its replication while ensuring cellular survival. Viral auxiliary proteins are a perfect paradigm to illustrate the complexity of the relationship between HIV and its host. Although these accessory proteins are mostly unnecessary for viral replication in permissive cells in vitro, they play a crucial role in regulating viral spread ex vivo in non-permissive cells and in vivo in hosts. Most accessory proteins are pleiotropic and instrumental in the counteraction of restriction factors and proteins involved in innate immune response.Several proteins of the “intrinsic” immune system that detect the presence of the assailant and initiate a subsequent immune response, as well as restriction factors that are directly devoted to arresting the replication cycle at precise steps have been characterized. Despite the numerous cellular mechanisms dedicated to preventing viral replication, HIV is able to efficiently replicate in humans. Indeed, as a master regulator of cellular machineries and processes, not only has HIV evolved strategies to avoid triggering of pattern recognition receptors, but HIV has also elaborated ways to counteract host restriction factors, thereby overcoming the hurdles that oppose efficient replication. English Microbiology & Immunology HILCC Biology HILCC Health & Biological Sciences HILCC HIV intracellular sensors restriction factors intrinsic immune system Viral accessory proteins Benkirane, Monsef editor. Laguette, Nadine editor. |
language |
English |
format |
eBook |
author |
Nadine Laguette |
spellingShingle |
Nadine Laguette Manipulation of the host cell by viral auxiliary proteins / Frontiers Research Topics |
author_facet |
Nadine Laguette Benkirane, Monsef Laguette, Nadine |
author_variant |
n l nl |
author2 |
Benkirane, Monsef Laguette, Nadine |
author2_variant |
m b mb n l nl |
author2_role |
TeilnehmendeR TeilnehmendeR |
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Nadine Laguette |
title |
Manipulation of the host cell by viral auxiliary proteins / |
title_full |
Manipulation of the host cell by viral auxiliary proteins / topic editors Nadine Laguette and Monsef Benkirane. |
title_fullStr |
Manipulation of the host cell by viral auxiliary proteins / topic editors Nadine Laguette and Monsef Benkirane. |
title_full_unstemmed |
Manipulation of the host cell by viral auxiliary proteins / topic editors Nadine Laguette and Monsef Benkirane. |
title_auth |
Manipulation of the host cell by viral auxiliary proteins / |
title_new |
Manipulation of the host cell by viral auxiliary proteins / |
title_sort |
manipulation of the host cell by viral auxiliary proteins / |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA Frontiers Media SA, |
publishDate |
2015 |
physical |
1 online resource (118 pages) : illustrations; digital, PDF file(s). |
isbn |
9782889194841 (ebook) |
callnumber-first |
Q - Science |
callnumber-subject |
QR - Microbiology |
callnumber-label |
QR41 |
callnumber-sort |
QR 241.2 |
illustrated |
Illustrated |
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