Comparative studies between HTLV-1 and HTLV-2 function and pathobiology / topic editors Umberto Bertazzoni and Françoise Bex.

• Author: Francoise Bex
• TeilnehmendeR: Bertazzoni, Umberto,; Bex, Françoise,
• Place / Publishing House: [Lausanne, Switzerland] : : Frontiers Media SA,, 2015.; ©2015
• Year of Publication: 2015
• Language: English
• Series: Frontiers research topics
• Physical Description: 1 online resource (94 pages) :; illustrations; digital, PDF file(s).
• Notes: Bibliographic Level Mode of Issuance: Monograph

Human T-cell leukemia viruses 1 and 2 (HTLV-1 and HTLV-2) have similar genomic structure but differ in pathogenicity. HTLV-1 is associated with ATL whereas HTLV-2 has not been linked to lymphoproliferative diseases. A comparative analysis between the two viruses is important to reach a better understanding of the difference in pathogenesis. A key role is attributed to the Tax proteins; Tax-1 function and structure has been thoroughly investigated but less is known about Tax-2. Recent studies on HTLV-1 and HTLV-2 expression strategies highlighted converging patterns as well as peculiar differences in the expression of regulatory proteins that might influence the pathobiology of these viruses. The study of interaction of regulatory proteins with cellular pathways factors has opened new avenues in understanding the mechanisms of gene transcription and deregulation. However, further investigation is needed on the role on innate immunity on HTLV-1 and HTLV-2 pathogenesis. Concerning the mechanisms of infection and related diseases and of their interaction with other co-infecting agents, the comparison between HTLV-1 and HTLV-2 needs further investigation.