Glial Cells: Managers of Neuro-immunity
Immune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and acti...
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Year of Publication: | 2016 |
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Gilles J. Guillemin auth Glial Cells: Managers of Neuro-immunity Glial Cells Frontiers Media SA 2016 1 electronic resource (224 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Immune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and actively recruit lymphocytes and monocytes to the damaged areas. Theoretically, these responses are designed to repair the brain damage. However, alterations, or a chronic perpetuation of these responses may underlie a number of neuro-pathologies. It is thought that each inflammatory scenario within the brain have a specific biochemical footprint characterized by the release of determined cytokines, chemokines and growing factors able to define particular immunological responses. Alongside, glial cells transform their cell body, become larger and develop higher number of branches adopting an active morphological phenotype. These changes are related with the search of interactions with other cells, such as bystander resident cells of the brain parenchyma, but also cells homing from the blood stream. In this process, microglia and astrocytes communicates with other cells by the formation of specific intercellular connections that are still poorly understood. These interactions are complex and entail the arrangement of cytoskeletal compounds, secretory and phagocytic domains. In this particular crosstalk there is a two-way communication in which glial cells and target cells come together establishing interfaces with specific information exchange. This way, glial cells orchestrate the particular response recruiting cellular subsets within the central nervous system and organizing the resolution of the brain damage. In this Frontiers Research Topic, we compile a selection of articles unfolding diverse aspects of glial-derived inflammation, focused on neurodegenerative diseases and other nervous system disorders, with special emphasis on microglia/macrophages as leading actors managing neuro-immunity. English astroglia neuroimmunology Neuroinflammation T cells glia Microglia 2-88919-835-9 Jeffrey M. Zirger auth Carlos Barcia auth James F. Curtin auth |
language |
English |
format |
eBook |
author |
Gilles J. Guillemin |
spellingShingle |
Gilles J. Guillemin Glial Cells: Managers of Neuro-immunity Frontiers Research Topics |
author_facet |
Gilles J. Guillemin Jeffrey M. Zirger Carlos Barcia James F. Curtin |
author_variant |
g j g gjg |
author2 |
Jeffrey M. Zirger Carlos Barcia James F. Curtin |
author2_variant |
j m z jmz c b cb j f c jfc |
author_sort |
Gilles J. Guillemin |
title |
Glial Cells: Managers of Neuro-immunity |
title_full |
Glial Cells: Managers of Neuro-immunity |
title_fullStr |
Glial Cells: Managers of Neuro-immunity |
title_full_unstemmed |
Glial Cells: Managers of Neuro-immunity |
title_auth |
Glial Cells: Managers of Neuro-immunity |
title_alt |
Glial Cells |
title_new |
Glial Cells: Managers of Neuro-immunity |
title_sort |
glial cells: managers of neuro-immunity |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (224 p.) |
isbn |
2-88919-835-9 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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is_hierarchy_title |
Glial Cells: Managers of Neuro-immunity |
container_title |
Frontiers Research Topics |
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