Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges
The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginni...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2017 |
Language: | English |
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Alessandro Lagana auth Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges Bioinformatics of Non-Coding RNAs with Applications to Biomedicine Frontiers Media SA 2017 1 electronic resource (95 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Open access Unrestricted online access star The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic. English CRISPR CLIPseq RNA Editing bioinformatics isomiRs microRNA siRNA ncRNA networks RNAseq 2-88945-096-1 Alfredo Ferro auth Carlo Maria Croce auth |
language |
English |
format |
eBook |
author |
Alessandro Lagana |
spellingShingle |
Alessandro Lagana Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges Frontiers Research Topics |
author_facet |
Alessandro Lagana Alfredo Ferro Carlo Maria Croce |
author_variant |
a l al |
author2 |
Alfredo Ferro Carlo Maria Croce |
author2_variant |
a f af c m c cmc |
author_sort |
Alessandro Lagana |
title |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
title_full |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
title_fullStr |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
title_full_unstemmed |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
title_auth |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
title_alt |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine |
title_new |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
title_sort |
bioinformatics of non-coding rnas with applications to biomedicine: recent advances and open challenges |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2017 |
physical |
1 electronic resource (95 p.) |
isbn |
2-88945-096-1 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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ids_txt_mv |
(CKB)3800000000216254 (oapen)https://directory.doabooks.org/handle/20.500.12854/42212 (EXLCZ)993800000000216254 |
carrierType_str_mv |
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hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges |
container_title |
Frontiers Research Topics |
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