Mechanisms of Innate Neuroprotection

Mechanisms of Innate Neuroprotection

As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioni...

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Superior document:Frontiers Research Topics
:
Giuseppe Pignataro
Year of Publication:2016
Language:English
Series:Frontiers Research Topics
Physical Description:1 electronic resource (138 p.)
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spelling Giuseppe Pignataro auth
Mechanisms of Innate Neuroprotection
Frontiers Media SA 2016
1 electronic resource (138 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Frontiers Research Topics
As clinical trials of pharmacological neuroprotective strategies in stroke have been disappointing, attention has turned to the brain's own endogenous strategies for neuroprotection. Two endogenous mechanisms have been recently characterized, ischemic preconditioning and ischemic postconditioning. In the present topic newly characterized mechanisms involved in preconditioning- and postconditioning- neuroprotection will be discussed. The understanding of the mechanisms involved in the neuroprotective pathways induced by preconditioning and postconditioning will be clinically relevant for identifying new druggable target for neurodegenerative disorder therapy. Furthermore, the importance of these neuroprotective strategies resides in that it might be easily translatable into clinical practice. Therefore, the data presented here will highlight the capacity of ischemic preconditioning and postconditioning to be of benefit to humans.
English
Neuroprotection
postconditioning
NCX
Stroke
seizure
miRNA
Alzheimer
preconditioning
2-88919-929-0
language English
format eBook
author Giuseppe Pignataro
spellingShingle Giuseppe Pignataro
Mechanisms of Innate Neuroprotection
Frontiers Research Topics
author_facet Giuseppe Pignataro
author_variant g p gp
author_sort Giuseppe Pignataro
title Mechanisms of Innate Neuroprotection
title_full Mechanisms of Innate Neuroprotection
title_fullStr Mechanisms of Innate Neuroprotection
title_full_unstemmed Mechanisms of Innate Neuroprotection
title_auth Mechanisms of Innate Neuroprotection
title_new Mechanisms of Innate Neuroprotection
title_sort mechanisms of innate neuroprotection
series Frontiers Research Topics
series2 Frontiers Research Topics
publisher Frontiers Media SA
publishDate 2016
physical 1 electronic resource (138 p.)
isbn 2-88919-929-0
illustrated Not Illustrated
work_keys_str_mv AT giuseppepignataro mechanismsofinnateneuroprotection
status_str n
ids_txt_mv (CKB)3800000000216258
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hierarchy_parent_title Frontiers Research Topics
is_hierarchy_title Mechanisms of Innate Neuroprotection
container_title Frontiers Research Topics
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