Glial Plasticity in Depression
Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation o...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (99 p.) |
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Luisa Pinto auth Glial Plasticity in Depression Frontiers Media SA 2016 1 electronic resource (99 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Major depression is a highly prevalent disorder that poses a significant social burden in society nowadays. The pathophysiology of this disease is still poorly understood but growing evidence suggests that impaired neuron and glial plasticity may be a key underlying mechanism for the precipitation of the disorder. One of the most surprising findings in this field was the involvement of glial cells in the pathophysiology of major depression and in the action of antidepressants, namely in mechanisms related with adult neurogenesis imbalances or dendritic arborization impairments. In particular, several works refer to alterations in the morphology and numbers of astrocytes, microglia and oligodendrocytes in the context of depression in human patients or animal models of depression. These observations were linked to functional evidences and suggested to underlie the pathophysiology of depression. Among others, these include impairments in the cross-talk between glia and neurons, changes in the level of neurotransmitter or immunoactive substances, myelination status, synapse formation, maintenance, or elimination. In addition to the implication of glia in the pathophysiology of depression, a number of studies is ascribing glia pathways to classically accepted antidepressant mechanisms. Therefore, it is noteworthy to elucidate the role of glia in the effect provided by antidepressant treatment in order to better understand secondary effects and elucidate alternative targets for treatment. English Neuron oligodendrocyte antidepressant Depression astrocyte Microglia 2-88919-999-1 Nuno Sousa auth Joao F. Oliveira auth Catarina A. Gomes auth Sandra H. Vaz auth |
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English |
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eBook |
author |
Luisa Pinto |
spellingShingle |
Luisa Pinto Glial Plasticity in Depression Frontiers Research Topics |
author_facet |
Luisa Pinto Nuno Sousa Joao F. Oliveira Catarina A. Gomes Sandra H. Vaz |
author_variant |
l p lp |
author2 |
Nuno Sousa Joao F. Oliveira Catarina A. Gomes Sandra H. Vaz |
author2_variant |
n s ns j f o jfo c a g cag s h v shv |
author_sort |
Luisa Pinto |
title |
Glial Plasticity in Depression |
title_full |
Glial Plasticity in Depression |
title_fullStr |
Glial Plasticity in Depression |
title_full_unstemmed |
Glial Plasticity in Depression |
title_auth |
Glial Plasticity in Depression |
title_new |
Glial Plasticity in Depression |
title_sort |
glial plasticity in depression |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (99 p.) |
isbn |
2-88919-999-1 |
illustrated |
Not Illustrated |
work_keys_str_mv |
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n |
ids_txt_mv |
(CKB)3800000000216320 (oapen)https://directory.doabooks.org/handle/20.500.12854/48665 (EXLCZ)993800000000216320 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Glial Plasticity in Depression |
container_title |
Frontiers Research Topics |
author2_original_writing_str_mv |
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1796652236569313281 |
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