Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology
The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation. Among the past years, several approaches to restore a suppressive immune state have included the targeting of co-stimulatory/inhibitory...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2016 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (143 p.) |
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Sergio Quezada auth Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology Frontiers Media SA 2016 1 electronic resource (143 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics The break on immune tolerance is a common point between autoimmune diseases and the uncontrolled effector immune responses against allo-antigens in transplantation. Among the past years, several approaches to restore a suppressive immune state have included the targeting of co-stimulatory/inhibitory molecules on immune cells, the promotion or blockade of pivotal cytokines, and the extensive study on how to isolate and expand suppressive cells with the purpose to re-infuse them in patients. To date, the availability of new technologies has permitted to learn, in a more detailed way, the immune mechanisms carried out by suppressive lymphocytes, together with the identification of new potential candidates to target in our quest for immune tolerance. For example, the attractive concepts of lymphocyte plasticity and function stability, supported by the finding of new transcription factors, have opened a new window in the understanding of T cell differentiation, effector cell commitment and immune regulatory function. On the other hand, the discovery of new members of the Ig superfamily ligand, VISTA; the intriguing role of modulatory molecules like Retinoic Acid, Neuropilin-1, Fc gamma receptors, or cytokines such as IL-33, among others, are revealing new possibilities in the development of new strategies to conquer our obsession: immune tolerance. Here, we gather the latest information regarding new targets and cellular processes, including an update on current cellular therapies and the exciting coming approaches to cure autoimmunity and permit transplant acceptance. English Autoimmunity immuneregulation Transplantation tolerance 2-88919-951-7 Juan C. Aguillon auth Pino-Lagos auth Diego Francisco Catalan auth |
language |
English |
format |
eBook |
author |
Sergio Quezada |
spellingShingle |
Sergio Quezada Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology Frontiers Research Topics |
author_facet |
Sergio Quezada Juan C. Aguillon Pino-Lagos Diego Francisco Catalan |
author_variant |
s q sq |
author2 |
Juan C. Aguillon Pino-Lagos Diego Francisco Catalan |
author2_variant |
j c a jca p l pl d f c dfc |
author_sort |
Sergio Quezada |
title |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
title_full |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
title_fullStr |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
title_full_unstemmed |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
title_auth |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
title_new |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
title_sort |
searching for immune tolerance manipulating new molecules and exploiting new concepts on lymphocyte biology |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2016 |
physical |
1 electronic resource (143 p.) |
isbn |
2-88919-951-7 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT sergioquezada searchingforimmunetolerancemanipulatingnewmoleculesandexploitingnewconceptsonlymphocytebiology AT juancaguillon searchingforimmunetolerancemanipulatingnewmoleculesandexploitingnewconceptsonlymphocytebiology AT pinolagos searchingforimmunetolerancemanipulatingnewmoleculesandexploitingnewconceptsonlymphocytebiology AT diegofranciscocatalan searchingforimmunetolerancemanipulatingnewmoleculesandexploitingnewconceptsonlymphocytebiology |
status_str |
n |
ids_txt_mv |
(CKB)3800000000216314 (oapen)https://directory.doabooks.org/handle/20.500.12854/59064 (EXLCZ)993800000000216314 |
carrierType_str_mv |
cr |
hierarchy_parent_title |
Frontiers Research Topics |
is_hierarchy_title |
Searching for Immune Tolerance Manipulating New Molecules and Exploiting New Concepts on Lymphocyte Biology |
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Frontiers Research Topics |
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