Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease
The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to unders...
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| Superior document: | Frontiers Research Topics |
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| Year of Publication: | 2017 |
| Language: | English |
| Series: | Frontiers Research Topics
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| Physical Description: | 1 electronic resource (183 p.) |
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Robert J. Harvey auth Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease Frontiers Media SA 2017 1 electronic resource (183 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants. English Stem Cells glycine receptor Amyotrophic Lateral Sclerosis Parkinson's disease PET imaging LRRK2 Zebrafish Inflammation GABA-A receptor NMDA receptors Intellectual Disability 2-88945-173-9 Kirsten Harvey auth |
| language |
English |
| format |
eBook |
| author |
Robert J. Harvey |
| spellingShingle |
Robert J. Harvey Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease Frontiers Research Topics |
| author_facet |
Robert J. Harvey Kirsten Harvey |
| author_variant |
r j h rjh |
| author2 |
Kirsten Harvey |
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k h kh |
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Robert J. Harvey |
| title |
Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_full |
Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_fullStr |
Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_full_unstemmed |
Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_auth |
Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_new |
Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
| title_sort |
molecular, cellular and model organism approaches for understanding the basis of neurological disease |
| series |
Frontiers Research Topics |
| series2 |
Frontiers Research Topics |
| publisher |
Frontiers Media SA |
| publishDate |
2017 |
| physical |
1 electronic resource (183 p.) |
| isbn |
2-88945-173-9 |
| illustrated |
Not Illustrated |
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Molecular, Cellular and Model Organism Approaches for Understanding the Basis of Neurological Disease |
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