Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs
Tens of thousands of chemicals are released into the environment every day. High-throughput screening (HTS) has offered a more efficient and cost-effective alternative to traditional toxicity tests that can profile these chemicals for potential adverse effects with the aim to prioritize a manageable...
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Superior document: | Frontiers Research Topics |
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Year of Publication: | 2017 |
Language: | English |
Series: | Frontiers Research Topics
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Physical Description: | 1 electronic resource (102 p.) |
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Xia, Menghang auth Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs Frontiers Media SA 2017 1 electronic resource (102 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Frontiers Research Topics Tens of thousands of chemicals are released into the environment every day. High-throughput screening (HTS) has offered a more efficient and cost-effective alternative to traditional toxicity tests that can profile these chemicals for potential adverse effects with the aim to prioritize a manageable number for more in depth testing and to provide clues to mechanism of toxicity. The Tox21 program, a collaboration between the National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP), the U.S. Environmental Protection Agency’s (EPA) National Center for Computational Toxicology (NCCT), the National Institutes of Health (NIH) National Center for Advancing Translational Sciences (NCATS), and the U.S. Food and Drug Administration (FDA), has generated quantitative high-throughput screening (qHTS) data on a library of 10K compounds, including environmental chemicals and drugs, against a panel of nuclear receptor and stress response pathway assays during its production phase (phase II). The Tox21 Challenge, a worldwide modeling competition, was launched that asks a “crowd” of researchers to use these data to elucidate the extent to which the interference of biochemical and cellular pathways by compounds can be inferred from chemical structure data. In the Challenge participants were asked to model twelve assays related to nuclear receptor and stress response pathways using the data generated against the Tox21 10K compound library as the training set. The computational models built within this Challenge are expected to improve the community’s ability to prioritize novel chemicals with respect to potential concern to human health. This research topic presents the resulting computational models with good predictive performance from this Challenge. English stress response predictive model QSAR HTS nuclear receptor in vitro assay Tox21 2-88945-197-6 Ruili Huang auth |
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English |
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author |
Xia, Menghang |
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Xia, Menghang Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs Frontiers Research Topics |
author_facet |
Xia, Menghang Ruili Huang |
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Ruili Huang |
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Xia, Menghang |
title |
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
title_full |
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
title_fullStr |
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
title_full_unstemmed |
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
title_auth |
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
title_new |
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
title_sort |
tox21 challenge to build predictive models of nuclear receptor and stress response pathways as mediated by exposure to environmental toxicants and drugs |
series |
Frontiers Research Topics |
series2 |
Frontiers Research Topics |
publisher |
Frontiers Media SA |
publishDate |
2017 |
physical |
1 electronic resource (102 p.) |
isbn |
2-88945-197-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT xiamenghang tox21challengetobuildpredictivemodelsofnuclearreceptorandstressresponsepathwaysasmediatedbyexposuretoenvironmentaltoxicantsanddrugs AT ruilihuang tox21challengetobuildpredictivemodelsofnuclearreceptorandstressresponsepathwaysasmediatedbyexposuretoenvironmentaltoxicantsanddrugs |
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(CKB)4100000000883848 (oapen)https://directory.doabooks.org/handle/20.500.12854/61064 (EXLCZ)994100000000883848 |
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Frontiers Research Topics |
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Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs |
container_title |
Frontiers Research Topics |
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1797909389966835712 |
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