New Aspects of Cancer Stem Cell Biology : Implications for Innovative Therapies
The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological charact...
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Cavallaro, Ugo edt New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies New Aspects of Cancer Stem Cell Biology Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020 1 electronic resource (208 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies. English Research & information: general bicssc Biology, life sciences bicssc Cadherin 11 WNT signaling β-catenin cancer stem cells TNBC early breast cancer bevacizumab neoadjuvant chemotherapy ALDH1 solid cancer chemo-resistance HDAC inhibitors head and neck squamous cell carcinoma SRC dasatinib saracatinib EC-8042 Ovarian cancer Wnt signaling tumor progression therapy resistance exosomes oral cancer risk oral epithelial dysplasia SOX2 immunohistochemistry oral squamous cell carcinoma genome-wide transcriptome lung cancer ATAC-seq RNA-seq CSCs NSCLC B4GALT1 LUAD breast cancer lipid metabolism therapeutic resistance bowel cancer organoid tumoroid colorectal colon stem cell chemotherapy resistance ovarian cancer cancer stem cell genetic heterogeneity SNP array L1CAM chemoresistance epithelial-mesenchymal transition cancer therapy cell adhesion molecule 3-03943-406-3 3-03943-407-1 Giordano, Marco edt Cavallaro, Ugo oth Giordano, Marco oth |
language |
English |
format |
eBook |
author2 |
Giordano, Marco Cavallaro, Ugo Giordano, Marco |
author_facet |
Giordano, Marco Cavallaro, Ugo Giordano, Marco |
author2_variant |
u c uc m g mg |
author2_role |
HerausgeberIn Sonstige Sonstige |
title |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
spellingShingle |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
title_sub |
Implications for Innovative Therapies |
title_full |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
title_fullStr |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
title_full_unstemmed |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
title_auth |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
title_alt |
New Aspects of Cancer Stem Cell Biology |
title_new |
New Aspects of Cancer Stem Cell Biology |
title_sort |
new aspects of cancer stem cell biology implications for innovative therapies |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
physical |
1 electronic resource (208 p.) |
isbn |
3-03943-406-3 3-03943-407-1 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT cavallarougo newaspectsofcancerstemcellbiologyimplicationsforinnovativetherapies AT giordanomarco newaspectsofcancerstemcellbiologyimplicationsforinnovativetherapies AT cavallarougo newaspectsofcancerstemcellbiology AT giordanomarco newaspectsofcancerstemcellbiology |
status_str |
n |
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(CKB)5400000000040926 (oapen)https://directory.doabooks.org/handle/20.500.12854/69328 (EXLCZ)995400000000040926 |
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is_hierarchy_title |
New Aspects of Cancer Stem Cell Biology Implications for Innovative Therapies |
author2_original_writing_str_mv |
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