Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with va...
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Ey, Elodie edt Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases Shankopathies Frontiers Media SA 2020 1 electronic resource (231 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons. English Science: general issues bicssc Neurosciences bicssc Shank neuropsychiatric disorders modulating factors brain regions 2-88963-567-8 Bourgeron, Thomas edt Boeckers, Tobias M. edt Kim, Eunjoon edt Han, Kihoon edt Ey, Elodie oth |
language |
English |
format |
eBook |
author2 |
Bourgeron, Thomas Boeckers, Tobias M. Kim, Eunjoon Han, Kihoon Ey, Elodie |
author_facet |
Bourgeron, Thomas Boeckers, Tobias M. Kim, Eunjoon Han, Kihoon Ey, Elodie |
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e e ee t b tb t m b tm tmb e k ek k h kh |
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HerausgeberIn HerausgeberIn HerausgeberIn HerausgeberIn Sonstige |
title |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
spellingShingle |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
title_full |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
title_fullStr |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
title_full_unstemmed |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
title_auth |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
title_alt |
Shankopathies |
title_new |
Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
title_sort |
shankopathies: shank protein deficiency-induced synaptic diseases |
publisher |
Frontiers Media SA |
publishDate |
2020 |
physical |
1 electronic resource (231 p.) |
isbn |
2-88963-567-8 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT eyelodie shankopathiesshankproteindeficiencyinducedsynapticdiseases AT bourgeronthomas shankopathiesshankproteindeficiencyinducedsynapticdiseases AT boeckerstobiasm shankopathiesshankproteindeficiencyinducedsynapticdiseases AT kimeunjoon shankopathiesshankproteindeficiencyinducedsynapticdiseases AT hankihoon shankopathiesshankproteindeficiencyinducedsynapticdiseases AT eyelodie shankopathies AT bourgeronthomas shankopathies AT boeckerstobiasm shankopathies AT kimeunjoon shankopathies AT hankihoon shankopathies |
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(CKB)5400000000046149 (oapen)https://directory.doabooks.org/handle/20.500.12854/73719 (EXLCZ)995400000000046149 |
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Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases |
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