Mitochondria: From Physiology to Pathology
Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translatio...
Saved in:
Sonstige: | |
---|---|
Year of Publication: | 2021 |
Language: | English |
Physical Description: | 1 electronic resource (196 p.) |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
993546181504498 |
---|---|
ctrlnum |
(CKB)5400000000045786 (oapen)https://directory.doabooks.org/handle/20.500.12854/76954 (EXLCZ)995400000000045786 |
collection |
bib_alma |
record_format |
marc |
spelling |
Bruni, Francesco edt Mitochondria: From Physiology to Pathology Mitochondria Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2021 1 electronic resource (196 p.) text txt rdacontent computer c rdamedia online resource cr rdacarrier Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control. English Research & information: general bicssc atherosclerosis carotid intima-media thickness mitochondrial mutations cardiovascular risk factors mitochondria mtDNA cristae mitochondrial fission mitochondrial fusion mitochondrial diseas mitochondrial dynamics mitoenergetics mitosteroidogenesis LH cAMP Leydig cell mitochondrial DNA segregation heteroplasmy selective elimination mitophagy mitochondrial engineered nucleases kinases phosphorylation disease PINK1 Parkinson's disease mitochondria homeostasis Cterm MELAS transmitochondrial cybrids aminoacyl-tRNA synthetases LARS2 mitochondrial disease therapeutic peptides FAD synthase FAD1 mitochondria localization Saccharomyces cerevisiae mRNA mitochondrial localization motif 3-0365-2151-8 3-0365-2152-6 Bruni, Francesco oth |
language |
English |
format |
eBook |
author2 |
Bruni, Francesco |
author_facet |
Bruni, Francesco |
author2_variant |
f b fb |
author2_role |
Sonstige |
title |
Mitochondria: From Physiology to Pathology |
spellingShingle |
Mitochondria: From Physiology to Pathology |
title_full |
Mitochondria: From Physiology to Pathology |
title_fullStr |
Mitochondria: From Physiology to Pathology |
title_full_unstemmed |
Mitochondria: From Physiology to Pathology |
title_auth |
Mitochondria: From Physiology to Pathology |
title_alt |
Mitochondria |
title_new |
Mitochondria: From Physiology to Pathology |
title_sort |
mitochondria: from physiology to pathology |
publisher |
MDPI - Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
physical |
1 electronic resource (196 p.) |
isbn |
3-0365-2151-8 3-0365-2152-6 |
illustrated |
Not Illustrated |
work_keys_str_mv |
AT brunifrancesco mitochondriafromphysiologytopathology AT brunifrancesco mitochondria |
status_str |
n |
ids_txt_mv |
(CKB)5400000000045786 (oapen)https://directory.doabooks.org/handle/20.500.12854/76954 (EXLCZ)995400000000045786 |
carrierType_str_mv |
cr |
is_hierarchy_title |
Mitochondria: From Physiology to Pathology |
author2_original_writing_str_mv |
noLinkedField |
_version_ |
1787548505721536512 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03819nam-a2200781z--4500</leader><controlfield tag="001">993546181504498</controlfield><controlfield tag="005">20231214133335.0</controlfield><controlfield tag="006">m o d </controlfield><controlfield tag="007">cr|mn|---annan</controlfield><controlfield tag="008">202201s2021 xx |||||o ||| 0|eng d</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(CKB)5400000000045786</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(oapen)https://directory.doabooks.org/handle/20.500.12854/76954</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EXLCZ)995400000000045786</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bruni, Francesco</subfield><subfield code="4">edt</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mitochondria: From Physiology to Pathology</subfield></datafield><datafield tag="246" ind1=" " ind2=" "><subfield code="a">Mitochondria</subfield></datafield><datafield tag="260" ind1=" " ind2=" "><subfield code="a">Basel, Switzerland</subfield><subfield code="b">MDPI - Multidisciplinary Digital Publishing Institute</subfield><subfield code="c">2021</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 electronic resource (196 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">computer</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">online resource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Mitochondria play an increasingly central role in the context of cellular physiology. These organelles possess their own genome (mtDNA), which is functionally coordinated with the nuclear genome. Mitochondrial gene expression is mediated by molecular processes (replication, transcription, translation, and assembly of respiratory chain complexes) that all take place within the mitochondria. Several aspects of mtDNA expression have already been well characterized, but many more either are under debate or have yet to be discovered. Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic ‘hubs’ are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue ‘Mitochondria: from Physiology to Pathology’ published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control.</subfield></datafield><datafield tag="546" ind1=" " ind2=" "><subfield code="a">English</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Research & information: general</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">atherosclerosis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">carotid intima-media thickness</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial mutations</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cardiovascular risk factors</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondria</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mtDNA</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cristae</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial fission</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial fusion</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial diseas</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial dynamics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitoenergetics</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitosteroidogenesis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LH</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">cAMP</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Leydig cell</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial DNA segregation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">heteroplasmy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">selective elimination</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitophagy</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial engineered nucleases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">kinases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">phosphorylation</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">disease</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">PINK1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Parkinson's disease</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondria homeostasis</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Cterm</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">MELAS</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">transmitochondrial cybrids</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">aminoacyl-tRNA synthetases</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">LARS2</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial disease</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">therapeutic peptides</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">FAD synthase</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">FAD1</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondria localization</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">Saccharomyces cerevisiae</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mRNA</subfield></datafield><datafield tag="653" ind1=" " ind2=" "><subfield code="a">mitochondrial localization motif</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-0365-2151-8</subfield></datafield><datafield tag="776" ind1=" " ind2=" "><subfield code="z">3-0365-2152-6</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bruni, Francesco</subfield><subfield code="4">oth</subfield></datafield><datafield tag="906" ind1=" " ind2=" "><subfield code="a">BOOK</subfield></datafield><datafield tag="ADM" ind1=" " ind2=" "><subfield code="b">2023-12-15 05:50:48 Europe/Vienna</subfield><subfield code="f">system</subfield><subfield code="c">marc21</subfield><subfield code="a">2022-04-04 09:22:53 Europe/Vienna</subfield><subfield code="g">false</subfield></datafield><datafield tag="AVE" ind1=" " ind2=" "><subfield code="i">DOAB Directory of Open Access Books</subfield><subfield code="P">DOAB Directory of Open Access Books</subfield><subfield code="x">https://eu02.alma.exlibrisgroup.com/view/uresolver/43ACC_OEAW/openurl?u.ignore_date_coverage=true&portfolio_pid=5338156970004498&Force_direct=true</subfield><subfield code="Z">5338156970004498</subfield><subfield code="b">Available</subfield><subfield code="8">5338156970004498</subfield></datafield></record></collection> |